Dual-responsive 3D DNA nanomachines cascaded hybridization chain reactions for novel self-powered flexible microRNA-detecting platform
Copyright © 2024 Elsevier B.V. All rights reserved..
The microRNA-21 is closely related to chromatin remodeling and epigenetic regulation. In this work, an efficient double-response 3D DNA nanomachine (DRDN) was assembled by co-immobilizing two different lengths of hairpin DNA on the surface of gold nanoparticles (AuNPs) to capture microRNA-21 (miRNA-21), recycle miRNA-21, and trigger hybridization chain reactions (HCR). This work reports the fabrication of a laser-scribed graphene (LSG) electrode with excellent flexibility and electrical conductivity by laser-scribing commercial polyimide films (PI). The as-proposed self-powered biosensing platform presents significantly increased instantaneous current to in real-time monitor miRNA-21 by a capacitor. The biosensing platform exhibited highly sensitive detection of miRNA-21 with a detection limit of 0.142 fM in the range of 0.5 fM to 1 × 104 fM, and demonstrated high efficiency in the analysis of the tumor markers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:252 |
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| Enthalten in: |
Biosensors & bioelectronics - 252(2024) vom: 15. März, Seite 116149 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Futing [VerfasserIn] |
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| Links: |
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| Themen: |
7440-57-5 |
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| Anmerkungen: |
Date Completed 06.03.2024 Date Revised 06.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bios.2024.116149 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The microRNA-21 is closely related to chromatin remodeling and epigenetic regulation. In this work, an efficient double-response 3D DNA nanomachine (DRDN) was assembled by co-immobilizing two different lengths of hairpin DNA on the surface of gold nanoparticles (AuNPs) to capture microRNA-21 (miRNA-21), recycle miRNA-21, and trigger hybridization chain reactions (HCR). This work reports the fabrication of a laser-scribed graphene (LSG) electrode with excellent flexibility and electrical conductivity by laser-scribing commercial polyimide films (PI). The as-proposed self-powered biosensing platform presents significantly increased instantaneous current to in real-time monitor miRNA-21 by a capacitor. The biosensing platform exhibited highly sensitive detection of miRNA-21 with a detection limit of 0.142 fM in the range of 0.5 fM to 1 × 104 fM, and demonstrated high efficiency in the analysis of the tumor markers | ||
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| 650 | 4 | |a Double-response 3D DNA nanomachine | |
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| 650 | 4 | |a Hybridization chain reactions | |
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| 700 | 1 | |a Zhang, Chunxiao |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Suping |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Yifei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Penghui |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Hongfen |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Lyu, Yifan |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Ren |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Weihong |e verfasserin |4 aut | |
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