Enhancing outcomes in deep brain stimulation : a comparative study of direct targeting using 7T versus 3T MRI
OBJECTIVE: The aim of this study was to compare outcomes of direct targeting in deep brain stimulation (DBS) for essential tremor using 7T MRI versus 3T MRI. The authors hypothesized that 7T MRI direct targeting would be noninferior to 3T MRI in early tremor outcomes.
METHODS: A retrospective study was conducted on patients undergoing unilateral thalamic DBS for essential tremor between 2021 and 2023. Two matched cohorts were assessed, one using 7T MRI and the other using 3T MRI for surgical planning. The primary endpoint was the percentage improvement in the Fahn-Tolosa-Marin Tremor Rating Scale (TRS) scores. Additionally, the authors assessed optimized programming settings and variance in electrode position on postoperative imaging. Demographic and clinical data were compared using the nonparametric Mann-Whitney U-test. The squared Euclidean distance of each contact from the group mean centroid was calculated and averaged across the entire cohort to provide the variance (i.e., the mean squared distance) of electrode contact position.
RESULTS: A total of 34 patients were analyzed, with 17 in each cohort. There were no significant differences in demographic information or mean surgical dates between the groups. There were no differences in intraoperative target repositioning or adverse events. The 7T group had a significantly greater TRS improvement than the 3T group (64.9% ± 11.4% vs 50.9% ± 16.4%, p = 0.004). Patients in the 7T cohort also had a lower mean stimulation current compared with those in the 3T cohort (2.0 ± 0.8 mA vs 2.7 ± 0.9 mA, p = 0.01). Image evaluation revealed that although the mean electrode position was comparable between 7T and 3T, the 7T electrode positioning was more clustered, indicating a lower variance in the final electrode location. The mean Euclidean distance between the individual electrode tips and the group centroid was significantly less at 7T than at 3T (1.82 ± 0.68 mm vs 2.75 ± 0.81 mm, p = 0.001).
CONCLUSIONS: Despite concerns for increased artifacts and distortions at 7T, the authors show that these effects can be mitigated with an appropriate workflow, leading to improved surgical outcomes with direct targeting using 7T MRI. Their results suggest similar accuracy but greater precision in targeting with 7T MRI compared with 3T MRI, resulting in lower stimulation currents and improved tremor reduction. Future studies are needed to assess outcomes related to 7T MRI in targeting other subcortical structures.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of neurosurgery - (2024) vom: 23. Feb., Seite 1-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Middlebrooks, Erik H [VerfasserIn] |
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| Links: |
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| Themen: |
7T MRI |
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| Anmerkungen: |
Date Revised 16.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.3171/2023.12.JNS232473 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36884644X |
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| 100 | 1 | |a Middlebrooks, Erik H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Enhancing outcomes in deep brain stimulation |b a comparative study of direct targeting using 7T versus 3T MRI |
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| 500 | |a Date Revised 16.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a OBJECTIVE: The aim of this study was to compare outcomes of direct targeting in deep brain stimulation (DBS) for essential tremor using 7T MRI versus 3T MRI. The authors hypothesized that 7T MRI direct targeting would be noninferior to 3T MRI in early tremor outcomes | ||
| 520 | |a METHODS: A retrospective study was conducted on patients undergoing unilateral thalamic DBS for essential tremor between 2021 and 2023. Two matched cohorts were assessed, one using 7T MRI and the other using 3T MRI for surgical planning. The primary endpoint was the percentage improvement in the Fahn-Tolosa-Marin Tremor Rating Scale (TRS) scores. Additionally, the authors assessed optimized programming settings and variance in electrode position on postoperative imaging. Demographic and clinical data were compared using the nonparametric Mann-Whitney U-test. The squared Euclidean distance of each contact from the group mean centroid was calculated and averaged across the entire cohort to provide the variance (i.e., the mean squared distance) of electrode contact position | ||
| 520 | |a RESULTS: A total of 34 patients were analyzed, with 17 in each cohort. There were no significant differences in demographic information or mean surgical dates between the groups. There were no differences in intraoperative target repositioning or adverse events. The 7T group had a significantly greater TRS improvement than the 3T group (64.9% ± 11.4% vs 50.9% ± 16.4%, p = 0.004). Patients in the 7T cohort also had a lower mean stimulation current compared with those in the 3T cohort (2.0 ± 0.8 mA vs 2.7 ± 0.9 mA, p = 0.01). Image evaluation revealed that although the mean electrode position was comparable between 7T and 3T, the 7T electrode positioning was more clustered, indicating a lower variance in the final electrode location. The mean Euclidean distance between the individual electrode tips and the group centroid was significantly less at 7T than at 3T (1.82 ± 0.68 mm vs 2.75 ± 0.81 mm, p = 0.001) | ||
| 520 | |a CONCLUSIONS: Despite concerns for increased artifacts and distortions at 7T, the authors show that these effects can be mitigated with an appropriate workflow, leading to improved surgical outcomes with direct targeting using 7T MRI. Their results suggest similar accuracy but greater precision in targeting with 7T MRI compared with 3T MRI, resulting in lower stimulation currents and improved tremor reduction. Future studies are needed to assess outcomes related to 7T MRI in targeting other subcortical structures | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 7T MRI | |
| 650 | 4 | |a deep brain stimulation | |
| 650 | 4 | |a direct targeting | |
| 650 | 4 | |a functional neurosurgery | |
| 650 | 4 | |a tremor | |
| 650 | 4 | |a ultra-high-field MRI | |
| 700 | 1 | |a Tipton, Philip W |e verfasserin |4 aut | |
| 700 | 1 | |a Greco, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Okromelidze, Lela |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Vishal |e verfasserin |4 aut | |
| 700 | 1 | |a Wszolek, Zbigniew K |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Xiangzhi |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, Shengzhen |e verfasserin |4 aut | |
| 700 | 1 | |a Westerhold, Erin M |e verfasserin |4 aut | |
| 700 | 1 | |a Straub, Sina |e verfasserin |4 aut | |
| 700 | 1 | |a Uitti, Ryan J |e verfasserin |4 aut | |
| 700 | 1 | |a Sandhu, Sukhwinder Johnny Singh |e verfasserin |4 aut | |
| 700 | 1 | |a Quiñones-Hinojosa, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Grewal, Sanjeet S |e verfasserin |4 aut | |
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