Chronic active Epstein-Barr virus infection mimicking tuberculosis - A diagnostic enigma
Copyright © 2023 Indian Journal of Pathology and Microbiology | Published by Wolters Kluwer – Medknow..
ABSTRACT: Chronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course. Clinico-pathological correlation with confirmation by ancillary techniques is inevitable to diagnose this disease. We present a case of a 29-year-old male with fever, weight loss, and lymphadenopathy for 6 months. Lymph node biopsy showed occasional granuloma with preserved architecture. Suspected to have tuberculosis, he received antitubercular treatment (ATT) with no response for 3 months. Subsequently, additional workup showed many EBV-positive cells in sinusoids with high serum EBV titer, confirming the difficult diagnosis of CAEBV. The present case highlights the difficulty in the diagnosis of this entity and also emphasizes the necessity to recognize this disorder in countries endemic for tuberculosis, as it is no longer bound by ethnicity and geographical boundaries.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Indian journal of pathology & microbiology - (2023) vom: 09. Nov. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Thakur, Shilpi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 23.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.4103/ijpm.ijpm_774_22 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368844137 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368844137 | ||
| 003 | DE-627 | ||
| 005 | 20240229150621.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240229s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4103/ijpm.ijpm_774_22 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1304.xml |
| 035 | |a (DE-627)NLM368844137 | ||
| 035 | |a (NLM)38394432 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Thakur, Shilpi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chronic active Epstein-Barr virus infection mimicking tuberculosis - A diagnostic enigma |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 23.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 Indian Journal of Pathology and Microbiology | Published by Wolters Kluwer – Medknow. | ||
| 520 | |a ABSTRACT: Chronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course. Clinico-pathological correlation with confirmation by ancillary techniques is inevitable to diagnose this disease. We present a case of a 29-year-old male with fever, weight loss, and lymphadenopathy for 6 months. Lymph node biopsy showed occasional granuloma with preserved architecture. Suspected to have tuberculosis, he received antitubercular treatment (ATT) with no response for 3 months. Subsequently, additional workup showed many EBV-positive cells in sinusoids with high serum EBV titer, confirming the difficult diagnosis of CAEBV. The present case highlights the difficulty in the diagnosis of this entity and also emphasizes the necessity to recognize this disorder in countries endemic for tuberculosis, as it is no longer bound by ethnicity and geographical boundaries | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Soneja, Manish |e verfasserin |4 aut | |
| 700 | 1 | |a Pushpam, Deepam |e verfasserin |4 aut | |
| 700 | 1 | |a Mallick, Saumyaranjan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Indian journal of pathology & microbiology |d 1993 |g (2023) vom: 09. Nov. |w (DE-627)NLM000276189 |x 0974-5130 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:09 |g month:11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4103/ijpm.ijpm_774_22 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 09 |c 11 | ||