Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections : a study among children ages 11 and 12 in the Danish National Birth Cohort
© 2024. The Author(s)..
BACKGROUND: The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates.
OBJECTIVES: To determine risk of RTIs in children ages 11 and 12 by residential exposures.
METHODS: We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living. We also estimated IRR and 95% CI for RTIs for predicted scores of four extracted factors ('owned house', 'mold and dampness', 'candles', and 'density') from exploratory factor analyses (EFA).
RESULTS: We included 42 720 children with complete data. Mold/dampness was associated with all RTIs (common cold: IRRadj 1.09[1.07, 1.12]; influenza: IRRadj 1.10 [1.05, 1.15]; tonsillitis: IRRadj 1.19 [1.10, 1.28]; conjunctivitis: IRRadj 1.16 [1.02, 1.32]; and doctor-diagnosed pneumonia: IRRadj 1.05 [0.90, 1.21]), as was the EFA factor 'mold/dampness' for several outcomes. Gas stove usage was associated with conjunctivitis (IRRadj 1.25 [1.05, 1.49]) and with doctor-diagnosed pneumonia (IRRadj 1.14 [0.93, 1.39]). Candle-burning during summer, but not winter, was associated with several RTIs, for tonsillitis in a dose-dependent fashion (increasing weekly frequencies vs. none: [IRRadj 1.06 [0.98, 1.14], IRRadj 1.16 [1.04, 1.30], IRRadj 1.23 [1.06, 1.43], IRRadj 1.29 [1.00, 1.67], and IRRadj 1.41 [1.12, 1.78]).
CONCLUSION: Residential exposures, in particular to mold and dampness and to a lesser degree to indoor combustion sources, are related to the occurrence of RTIs in children.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
European journal of epidemiology - 39(2024), 3 vom: 23. März, Seite 299-311 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Groot, Jonathan [VerfasserIn] |
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| Links: |
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| Themen: |
Built environment |
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| Anmerkungen: |
Date Completed 05.04.2024 Date Revised 18.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10654-024-01101-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Groot, Jonathan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections |b a study among children ages 11 and 12 in the Danish National Birth Cohort |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 05.04.2024 | ||
| 500 | |a Date Revised 18.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates | ||
| 520 | |a OBJECTIVES: To determine risk of RTIs in children ages 11 and 12 by residential exposures | ||
| 520 | |a METHODS: We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living. We also estimated IRR and 95% CI for RTIs for predicted scores of four extracted factors ('owned house', 'mold and dampness', 'candles', and 'density') from exploratory factor analyses (EFA) | ||
| 520 | |a RESULTS: We included 42 720 children with complete data. Mold/dampness was associated with all RTIs (common cold: IRRadj 1.09[1.07, 1.12]; influenza: IRRadj 1.10 [1.05, 1.15]; tonsillitis: IRRadj 1.19 [1.10, 1.28]; conjunctivitis: IRRadj 1.16 [1.02, 1.32]; and doctor-diagnosed pneumonia: IRRadj 1.05 [0.90, 1.21]), as was the EFA factor 'mold/dampness' for several outcomes. Gas stove usage was associated with conjunctivitis (IRRadj 1.25 [1.05, 1.49]) and with doctor-diagnosed pneumonia (IRRadj 1.14 [0.93, 1.39]). Candle-burning during summer, but not winter, was associated with several RTIs, for tonsillitis in a dose-dependent fashion (increasing weekly frequencies vs. none: [IRRadj 1.06 [0.98, 1.14], IRRadj 1.16 [1.04, 1.30], IRRadj 1.23 [1.06, 1.43], IRRadj 1.29 [1.00, 1.67], and IRRadj 1.41 [1.12, 1.78]) | ||
| 520 | |a CONCLUSION: Residential exposures, in particular to mold and dampness and to a lesser degree to indoor combustion sources, are related to the occurrence of RTIs in children | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Built environment | |
| 650 | 4 | |a Danish National Birth Cohort | |
| 650 | 4 | |a Environmental epidemiology | |
| 650 | 4 | |a Home | |
| 650 | 4 | |a Indoor air pollution | |
| 650 | 4 | |a Respiratory tract infections | |
| 700 | 1 | |a Keller, Amélie |e verfasserin |4 aut | |
| 700 | 1 | |a Sigsgaard, Torben |e verfasserin |4 aut | |
| 700 | 1 | |a Loft, Steffen |e verfasserin |4 aut | |
| 700 | 1 | |a Nybo Andersen, Anne-Marie |e verfasserin |4 aut | |
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