The curious case of T-cell mediated renal allograft rejection after Covid-19 infection
Copyright © 2023 Copyright: © 2023 Indian Journal of Pathology and Microbiology..
ABSTRACT: Our case illustrates the possible explanation of renal allograft rejection in a patient who had recovered from Covid-19 infection in the post-transplant period, which ultimately led to the death of the patient. A 27-year-old male patient received renal allograft from his mother, with an uneventful post-transplant period. Three years after the transplantation he contracted Covid-19 infection. The patient recovered from Covid-19 infection after being treated according to the treatment protocol. Subsequently, in the next 2 weeks, he presented with heavy proteinuria and a rise in serum creatinine level. Renal biopsy examination showed features of acute T-cell mediated rejection (TCMR) without any evidence of antibody-mediated rejection. He was given all due care but he deteriorated quickly leading to his death. This case highlights the inter-relation between Covid-19 infection and acute TCMR of the renal allograft, where renal biopsy serves as an indispensable tool in understanding its pathophysiology.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Indian journal of pathology & microbiology - (2023) vom: 10. Juli |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Basu, Keya [VerfasserIn] |
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| Links: |
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Date Revised 23.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.4103/ijpm.ijpm_584_22 |
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| funding: |
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| PPN (Katalog-ID): |
NLM368813347 |
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| 520 | |a Copyright © 2023 Copyright: © 2023 Indian Journal of Pathology and Microbiology. | ||
| 520 | |a ABSTRACT: Our case illustrates the possible explanation of renal allograft rejection in a patient who had recovered from Covid-19 infection in the post-transplant period, which ultimately led to the death of the patient. A 27-year-old male patient received renal allograft from his mother, with an uneventful post-transplant period. Three years after the transplantation he contracted Covid-19 infection. The patient recovered from Covid-19 infection after being treated according to the treatment protocol. Subsequently, in the next 2 weeks, he presented with heavy proteinuria and a rise in serum creatinine level. Renal biopsy examination showed features of acute T-cell mediated rejection (TCMR) without any evidence of antibody-mediated rejection. He was given all due care but he deteriorated quickly leading to his death. This case highlights the inter-relation between Covid-19 infection and acute TCMR of the renal allograft, where renal biopsy serves as an indispensable tool in understanding its pathophysiology | ||
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