Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19
BackgroundWaning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals are subject to biases.AimWe examined the association between time since vaccination and laboratory-confirmed influenza to assess the change in influenza vaccine protection over time.MethodsUsing linked laboratory and health administrative databases in Ontario, Canada, we identified community-dwelling individuals aged ≥ 6 months who received an influenza vaccine before being tested for influenza by RT-PCR during the 2010/11 to 2018/19 influenza seasons. We estimated the adjusted odds ratio (aOR) for laboratory-confirmed influenza by time since vaccination (categorised into intervals) and for every 28 days.ResultsThere were 53,065 individuals who were vaccinated before testing for influenza, with 10,264 (19%) influenza-positive cases. The odds of influenza increased from 1.05 (95% CI: 0.91-1.22) at 42-69 days after vaccination and peaked at 1.27 (95% CI: 1.04-1.55) at 126-153 days when compared with the reference interval (14-41 days). This corresponded to 1.09-times increased odds of influenza every 28 days (aOR = 1.09; 95% CI: 1.04-1.15). Individuals aged 18-64 years showed the greatest decline in protection against influenza A(H1N1) (aORper 28 days = 1.26; 95% CI: 0.97-1.64), whereas for individuals aged ≥ 65 years, it was against influenza A(H3N2) (aORper 28 days = 1.20; 95% CI: 1.08-1.33). We did not observe evidence of waning vaccine protection for individuals aged < 18 years.ConclusionsInfluenza vaccine protection wanes during an influenza season. Understanding the optimal timing of vaccination could ensure robust protection during seasonal influenza activity.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
|---|---|
| Enthalten in: |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 29(2024), 8 vom: 22. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chung, Hannah [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Influenza Vaccines |
|---|
| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 01.03.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2807/1560-7917.ES.2024.29.8.2300239 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368806367 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368806367 | ||
| 003 | DE-627 | ||
| 005 | 20240301232633.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240229s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2807/1560-7917.ES.2024.29.8.2300239 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1313.xml |
| 035 | |a (DE-627)NLM368806367 | ||
| 035 | |a (NLM)38390652 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chung, Hannah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19 |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.02.2024 | ||
| 500 | |a Date Revised 01.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BackgroundWaning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals are subject to biases.AimWe examined the association between time since vaccination and laboratory-confirmed influenza to assess the change in influenza vaccine protection over time.MethodsUsing linked laboratory and health administrative databases in Ontario, Canada, we identified community-dwelling individuals aged ≥ 6 months who received an influenza vaccine before being tested for influenza by RT-PCR during the 2010/11 to 2018/19 influenza seasons. We estimated the adjusted odds ratio (aOR) for laboratory-confirmed influenza by time since vaccination (categorised into intervals) and for every 28 days.ResultsThere were 53,065 individuals who were vaccinated before testing for influenza, with 10,264 (19%) influenza-positive cases. The odds of influenza increased from 1.05 (95% CI: 0.91-1.22) at 42-69 days after vaccination and peaked at 1.27 (95% CI: 1.04-1.55) at 126-153 days when compared with the reference interval (14-41 days). This corresponded to 1.09-times increased odds of influenza every 28 days (aOR = 1.09; 95% CI: 1.04-1.15). Individuals aged 18-64 years showed the greatest decline in protection against influenza A(H1N1) (aORper 28 days = 1.26; 95% CI: 0.97-1.64), whereas for individuals aged ≥ 65 years, it was against influenza A(H3N2) (aORper 28 days = 1.20; 95% CI: 1.08-1.33). We did not observe evidence of waning vaccine protection for individuals aged < 18 years.ConclusionsInfluenza vaccine protection wanes during an influenza season. Understanding the optimal timing of vaccination could ensure robust protection during seasonal influenza activity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Influenza vaccine | |
| 650 | 4 | |a vaccine effectiveness | |
| 650 | 4 | |a waning immunity | |
| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Campitelli, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Buchan, Sarah A |e verfasserin |4 aut | |
| 700 | 1 | |a Campigotto, Aaron |e verfasserin |4 aut | |
| 700 | 1 | |a Crowcroft, Natasha S |e verfasserin |4 aut | |
| 700 | 1 | |a Gubbay, Jonathan B |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, James Kh |e verfasserin |4 aut | |
| 700 | 1 | |a Karnauchow, Timothy |e verfasserin |4 aut | |
| 700 | 1 | |a Katz, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a McGeer, Allison J |e verfasserin |4 aut | |
| 700 | 1 | |a McNally, J Dayre |e verfasserin |4 aut | |
| 700 | 1 | |a Richardson, David C |e verfasserin |4 aut | |
| 700 | 1 | |a Richardson, Susan E |e verfasserin |4 aut | |
| 700 | 1 | |a Rosella, Laura C |e verfasserin |4 aut | |
| 700 | 1 | |a Russell, Margaret L |e verfasserin |4 aut | |
| 700 | 1 | |a Schwartz, Kevin L |e verfasserin |4 aut | |
| 700 | 1 | |a Simor, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Smieja, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Sundaram, Maria E |e verfasserin |4 aut | |
| 700 | 1 | |a Warshawsky, Bryna F |e verfasserin |4 aut | |
| 700 | 1 | |a Zahariadis, George |e verfasserin |4 aut | |
| 700 | 1 | |a Kwong, Jeffrey C |e verfasserin |4 aut | |
| 700 | 0 | |a Canadian Immunization Research Network (CIRN) Provincial Collaborative Network (PCN) Investigators |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |d 1995 |g 29(2024), 8 vom: 22. Feb. |w (DE-627)NLM115683283 |x 1560-7917 |7 nnns |
| 773 | 1 | 8 | |g volume:29 |g year:2024 |g number:8 |g day:22 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2807/1560-7917.ES.2024.29.8.2300239 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 29 |j 2024 |e 8 |b 22 |c 02 | ||