Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool : immune regulation, MSC priming, and applications to SLE
Copyright © 2024 Wong, Stoilova, Gazeau, Herbeuval and Fourniols..
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) are nanometer-sized particles carrying a diverse range of bioactive molecules, such as proteins, miRNAs, and lipids. Despite the methodological disparities, recent works on MSC-EVs have highlighted their broad immunosuppressive effect, thus driving forwards the potential of MSC-EVs in the treatment of chronic diseases. Nonetheless, their mechanism of action is still unclear, and better understanding is needed for clinical application. Therefore, we describe in this review the diverse range of bioactive molecules mediating their immunomodulatory effect, the techniques and possibilities for enhancing their immune activity, and finally the potential application to SLE.
| Errataetall: |
ErratumIn: Front Immunol. 2024 Apr 08;15:1386412. - PMID 38650944 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Frontiers in immunology - 15(2024) vom: 26., Seite 1355845 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wong, Christophe [VerfasserIn] |
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| Links: |
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| Themen: |
Extracellular vesicles |
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| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 26.04.2024 published: Electronic-eCollection ErratumIn: Front Immunol. 2024 Apr 08;15:1386412. - PMID 38650944 Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2024.1355845 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36880318X |
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| 500 | |a ErratumIn: Front Immunol. 2024 Apr 08;15:1386412. - PMID 38650944 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Wong, Stoilova, Gazeau, Herbeuval and Fourniols. | ||
| 520 | |a Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) are nanometer-sized particles carrying a diverse range of bioactive molecules, such as proteins, miRNAs, and lipids. Despite the methodological disparities, recent works on MSC-EVs have highlighted their broad immunosuppressive effect, thus driving forwards the potential of MSC-EVs in the treatment of chronic diseases. Nonetheless, their mechanism of action is still unclear, and better understanding is needed for clinical application. Therefore, we describe in this review the diverse range of bioactive molecules mediating their immunomodulatory effect, the techniques and possibilities for enhancing their immune activity, and finally the potential application to SLE | ||
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| 650 | 4 | |a extracellular vesicles | |
| 650 | 4 | |a immune regulation | |
| 650 | 4 | |a mesenchymal stromal cell | |
| 650 | 4 | |a priming | |
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| 650 | 4 | |a systemic lupus erythematosus | |
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| 700 | 1 | |a Gazeau, Florence |e verfasserin |4 aut | |
| 700 | 1 | |a Herbeuval, Jean-Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Fourniols, Thibaut |e verfasserin |4 aut | |
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