Diterpenoids from Torreya grandis and their cytotoxic activities
Copyright © 2024 Elsevier Ltd. All rights reserved..
Eight previously undescribed diterpenoids, along with eleven previously reported analogues, were obtained from the supercritical CO2 extracts of Torreya grandis aril. The structures of these compounds were elucidated based on HRESIMS, NMR, ECD, and single-crystal X-ray diffraction data. In the MTT assay, compound 18 exhibited significant inhibitory effects on two human colon cancer cell lines, HT-29 and HCT 116 cells, with IC50 values of 7.37 μM and 6.55 μM, respectively. It was found that compound 18 induced apoptosis and significantly inhibited the migration of HCT 116 colon cancer cells in a concentration-dependent manner.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
Phytochemistry - 221(2024) vom: 28. Apr., Seite 114036 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Zongyu [VerfasserIn] |
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| Links: |
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| Themen: |
31112-66-0 |
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| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.phytochem.2024.114036 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Eight previously undescribed diterpenoids, along with eleven previously reported analogues, were obtained from the supercritical CO2 extracts of Torreya grandis aril. The structures of these compounds were elucidated based on HRESIMS, NMR, ECD, and single-crystal X-ray diffraction data. In the MTT assay, compound 18 exhibited significant inhibitory effects on two human colon cancer cell lines, HT-29 and HCT 116 cells, with IC50 values of 7.37 μM and 6.55 μM, respectively. It was found that compound 18 induced apoptosis and significantly inhibited the migration of HCT 116 colon cancer cells in a concentration-dependent manner | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Cytotoxicity | |
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| 650 | 7 | |a Triiodobenzoic Acids |2 NLM | |
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| 700 | 1 | |a Dong, Minjian |e verfasserin |4 aut | |
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| 700 | 1 | |a Gu, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Chengxin |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Shiji |e verfasserin |4 aut | |
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