Investigating the Antibody Imprinting Hypothesis among Canadian Paramedics after SARS-CoV-2 Omicron Variant Circulation
Copyright © 2024 The Authors..
Recent research has highlighted the Omicron variant's capacity to evade immune protection conferred by wild-type (WT) mRNA vaccines. Despite this observation, the potential involvement of antigenic sin phenomena remains unclear. Our hypothesis posited that a greater number of prior WT vaccine doses might lead to reduced anti-Omicron neutralization Abs following Omicron infection. To investigate this, we analyzed blood samples from human participants in the COVID-19 Occupational Risk, Seroprevalence, and Immunity among Paramedics (CORSIP) study who had received at least one WT mRNA vaccine before contracting Omicron. The exposure variable was the number of WT mRNA vaccines administered, and the outcome was the angiotensin-converting enzyme 2 (ACE-2) percent inhibition specific to the BA.4/BA.5 Omicron Ag. Contrary to expectations, our findings revealed that more WT-based vaccines were associated with an enhanced Omicron-specific immune response.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
---|---|
Enthalten in: |
ImmunoHorizons - 8(2024), 2 vom: 01. Feb., Seite 193-197 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Asamoah-Boaheng, Michael [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Completed 26.02.2024 Date Revised 08.03.2024 published: Print Citation Status MEDLINE |
---|
doi: |
10.4049/immunohorizons.2400010 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368765954 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368765954 | ||
003 | DE-627 | ||
005 | 20240308232604.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240229s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.4049/immunohorizons.2400010 |2 doi | |
028 | 5 | 2 | |a pubmed24n1320.xml |
035 | |a (DE-627)NLM368765954 | ||
035 | |a (NLM)38386593 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Asamoah-Boaheng, Michael |e verfasserin |4 aut | |
245 | 1 | 0 | |a Investigating the Antibody Imprinting Hypothesis among Canadian Paramedics after SARS-CoV-2 Omicron Variant Circulation |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 26.02.2024 | ||
500 | |a Date Revised 08.03.2024 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 The Authors. | ||
520 | |a Recent research has highlighted the Omicron variant's capacity to evade immune protection conferred by wild-type (WT) mRNA vaccines. Despite this observation, the potential involvement of antigenic sin phenomena remains unclear. Our hypothesis posited that a greater number of prior WT vaccine doses might lead to reduced anti-Omicron neutralization Abs following Omicron infection. To investigate this, we analyzed blood samples from human participants in the COVID-19 Occupational Risk, Seroprevalence, and Immunity among Paramedics (CORSIP) study who had received at least one WT mRNA vaccine before contracting Omicron. The exposure variable was the number of WT mRNA vaccines administered, and the outcome was the angiotensin-converting enzyme 2 (ACE-2) percent inhibition specific to the BA.4/BA.5 Omicron Ag. Contrary to expectations, our findings revealed that more WT-based vaccines were associated with an enhanced Omicron-specific immune response | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a mRNA Vaccines |2 NLM | |
650 | 7 | |a Antibodies |2 NLM | |
700 | 1 | |a Grunau, Brian |e verfasserin |4 aut | |
700 | 1 | |a Karim, Mohammad Ehsanul |e verfasserin |4 aut | |
700 | 1 | |a Kayda, Iryna |e verfasserin |4 aut | |
700 | 1 | |a Yap, Justin |e verfasserin |4 aut | |
700 | 1 | |a Bessai, Katherine |e verfasserin |4 aut | |
700 | 1 | |a Goldfarb, David M |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t ImmunoHorizons |d 2017 |g 8(2024), 2 vom: 01. Feb., Seite 193-197 |w (DE-627)NLM274884070 |x 2573-7732 |7 nnns |
773 | 1 | 8 | |g volume:8 |g year:2024 |g number:2 |g day:01 |g month:02 |g pages:193-197 |
856 | 4 | 0 | |u http://dx.doi.org/10.4049/immunohorizons.2400010 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 8 |j 2024 |e 2 |b 01 |c 02 |h 193-197 |