Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H+ natural killer (NK) cells, which are virus specific and considered to be "adaptive" or "memory" NK cells. Here, we find that signaling lymphocytic activation molecule family receptors (SFRs), a group of hematopoietic cell-restricted receptors, are essential for the expansion of Ly49H+ NK cells after MCMV infection. This activity is largely mediated by CD48, an SFR broadly expressed on NK cells and displaying augmented expression after MCMV infection. It is also dependent on the CD48 counter-receptor, 2B4, expressed on host macrophages. The 2B4-CD48 axis promotes expansion of Ly49H+ NK cells by repressing their phagocytosis by virus-activated macrophages through inhibition of the pro-phagocytic integrin lymphocyte function-associated antigen-1 (LFA-1) on macrophages. These data identify key roles of macrophages and the 2B4-CD48 pathway in controlling the expansion of adaptive NK cells following MCMV infection. Stimulation of the 2B4-CD48 axis may be helpful in enhancing adaptive NK cell responses for therapeutic purposes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cell reports - 43(2024), 3 vom: 26. März, Seite 113800 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Rui [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2024.113800 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368765601 |
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| 245 | 1 | 0 | |a Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48 |
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| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H+ natural killer (NK) cells, which are virus specific and considered to be "adaptive" or "memory" NK cells. Here, we find that signaling lymphocytic activation molecule family receptors (SFRs), a group of hematopoietic cell-restricted receptors, are essential for the expansion of Ly49H+ NK cells after MCMV infection. This activity is largely mediated by CD48, an SFR broadly expressed on NK cells and displaying augmented expression after MCMV infection. It is also dependent on the CD48 counter-receptor, 2B4, expressed on host macrophages. The 2B4-CD48 axis promotes expansion of Ly49H+ NK cells by repressing their phagocytosis by virus-activated macrophages through inhibition of the pro-phagocytic integrin lymphocyte function-associated antigen-1 (LFA-1) on macrophages. These data identify key roles of macrophages and the 2B4-CD48 pathway in controlling the expansion of adaptive NK cells following MCMV infection. Stimulation of the 2B4-CD48 axis may be helpful in enhancing adaptive NK cell responses for therapeutic purposes | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a CD48 | |
| 650 | 4 | |a CP: Immunology | |
| 650 | 4 | |a LFA-1 | |
| 650 | 4 | |a MCMV | |
| 650 | 4 | |a SLAM family receptors | |
| 650 | 4 | |a adaptive NK cells | |
| 650 | 4 | |a anti-viral immunity | |
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| 650 | 4 | |a memory NK cells | |
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| 700 | 1 | |a Galindo, Cristian Camilo |e verfasserin |4 aut | |
| 700 | 1 | |a Davidson, Dominique |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Huaijian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Ming-Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Ruzsics, Zsolt |e verfasserin |4 aut | |
| 700 | 1 | |a Lau, Colleen M |e verfasserin |4 aut | |
| 700 | 1 | |a O'Sullivan, Timothy E |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Silvia M |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Joseph C |e verfasserin |4 aut | |
| 700 | 1 | |a Veillette, André |e verfasserin |4 aut | |
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