Associations of thyroid feedback quantile-based index with diabetes in euthyroid adults in the United States and China
BACKGROUND: We aimed to investigate the associations between thyroid hormone sensitivity indices and diabetes in euthyroid adults in the United States and China.
METHODS: 2296 euthyroid adults from the NHANES in the United States and 8319 euthyroid adults from the SPEED-Shunde in China were involved. The thyroid sensitivity indices, namely TFQIFT4 and TFQIFT3, were calculated. Multivariable logistic regression, restricted cubic spline analysis, and general ordinal logit regression were utilized.
RESULTS: In the NHANES, compared with participants in quartile 1st (Q1), those in Q4 of TFQIFT3 (OR 2.12, 95% CI (1.18, 3.81)) and those in Q3 of TFQIFT4 (OR 2.31, 95% CI (1.18, 4.53)) (both P for trend < 0.05) were associated with a greater prevalence of diabetes. In the SPEED-Shunde, compared with participants in Q1, those in Q4 of TFQIFT3 had a greater prevalence of diabetes (OR 1.36, 95% CI (1.11, 1.66) (P for trend < 0.05), while no significant associations between TFQIFT4 and diabetes were found.
CONCLUSIONS: TFQIFT3 was associated with a higher prevalence of diabetes both in the United States and China. However, TFQIFT4 was only associated with a higher prevalence of diabetes in the United States, not in China. Further prospective cohort studies are necessary to validate these findings.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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Enthalten in: |
Annals of medicine - 56(2024), 1 vom: 19. Feb., Seite 2318418 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wan, Heng [VerfasserIn] |
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Links: |
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Themen: |
Diabetes |
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Anmerkungen: |
Date Completed 23.02.2024 Date Revised 24.02.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1080/07853890.2024.2318418 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM368726525 |
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520 | |a BACKGROUND: We aimed to investigate the associations between thyroid hormone sensitivity indices and diabetes in euthyroid adults in the United States and China | ||
520 | |a METHODS: 2296 euthyroid adults from the NHANES in the United States and 8319 euthyroid adults from the SPEED-Shunde in China were involved. The thyroid sensitivity indices, namely TFQIFT4 and TFQIFT3, were calculated. Multivariable logistic regression, restricted cubic spline analysis, and general ordinal logit regression were utilized | ||
520 | |a RESULTS: In the NHANES, compared with participants in quartile 1st (Q1), those in Q4 of TFQIFT3 (OR 2.12, 95% CI (1.18, 3.81)) and those in Q3 of TFQIFT4 (OR 2.31, 95% CI (1.18, 4.53)) (both P for trend < 0.05) were associated with a greater prevalence of diabetes. In the SPEED-Shunde, compared with participants in Q1, those in Q4 of TFQIFT3 had a greater prevalence of diabetes (OR 1.36, 95% CI (1.11, 1.66) (P for trend < 0.05), while no significant associations between TFQIFT4 and diabetes were found | ||
520 | |a CONCLUSIONS: TFQIFT3 was associated with a higher prevalence of diabetes both in the United States and China. However, TFQIFT4 was only associated with a higher prevalence of diabetes in the United States, not in China. Further prospective cohort studies are necessary to validate these findings | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Impaired sensitivity to thyroid hormones | |
650 | 4 | |a TFQI | |
650 | 4 | |a diabetes | |
700 | 1 | |a Yu, Genfeng |e verfasserin |4 aut | |
700 | 1 | |a He, Yajun |e verfasserin |4 aut | |
700 | 1 | |a Liu, Siyang |e verfasserin |4 aut | |
700 | 1 | |a Chen, Xingying |e verfasserin |4 aut | |
700 | 1 | |a Jiang, Yuqi |e verfasserin |4 aut | |
700 | 1 | |a Duan, Hualin |e verfasserin |4 aut | |
700 | 1 | |a Lin, Xu |e verfasserin |4 aut | |
700 | 1 | |a Liu, Lan |e verfasserin |4 aut | |
700 | 1 | |a Shen, Jie |e verfasserin |4 aut | |
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