Meta-analysis of initial natriuretic peptides in the setting of sepsis-induced myocardial dysfunction

Aim: To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0. Methods: Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups. Results: Eighteen studies were included, most of which defined SIMD based on echocardiography. The SIMD group exhibited higher initial BNP and NT-proBNP levels in blood. NT-proBNP higher than a certain cutoff value (>3000 pg/ml) was an independent risk factor for SIMD and its accuracy for SIMD diagnosis was moderate (pooled area under the curve: 0.81). Conclusion: Initial blood BNP and NT-proBNP levels are useful to assist in the detection of SIMD and further studies are warranted to determine the SIMD definition.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Biomarkers in medicine - 18(2024), 4 vom: 13. Feb., Seite 145-155

Sprache:

Englisch

Beteiligte Personen:

He, Boyong [VerfasserIn]
Wang, Xin [VerfasserIn]
Shi, Liguo [VerfasserIn]
Cheng, Hongbin [VerfasserIn]
Zhao, Luyi [VerfasserIn]

Links:

Volltext

Themen:

114471-18-0
Biomarkers
Journal Article
Meta-Analysis
Meta-analysis
Myocardial dysfunction
Natriuretic Peptide, Brain
Natriuretic Peptides
Natriuretic peptide
Peptide Fragments
Review
Sepsis

Anmerkungen:

Date Completed 15.03.2024

Date Revised 15.03.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.2217/bmm-2023-0605

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM368710181