3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model
This journal is © The Royal Society of Chemistry..
Implantable polymeric hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology. The CPMV-laden hydrogels were surgically implanted into the peritoneal cavity to serve as depots for cancer slow-release immunotherapy. Sustained release of CPMV within the intraperitoneal space alleviates the need for repeated dosing and we demonstrated efficacy against ovarian cancer in a metastatic mouse model.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Materials advances - 5(2024), 4 vom: 19. Feb., Seite 1480-1486 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Zhongchao [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 22.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d3ma00899a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Implantable polymeric hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology. The CPMV-laden hydrogels were surgically implanted into the peritoneal cavity to serve as depots for cancer slow-release immunotherapy. Sustained release of CPMV within the intraperitoneal space alleviates the need for repeated dosing and we demonstrated efficacy against ovarian cancer in a metastatic mouse model | ||
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| 700 | 1 | |a Koellhoffer, Edward C |e verfasserin |4 aut | |
| 700 | 1 | |a Shukla, Sourabh |e verfasserin |4 aut | |
| 700 | 1 | |a Fiering, Steven |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shaochen |e verfasserin |4 aut | |
| 700 | 1 | |a Steinmetz, Nicole F |e verfasserin |4 aut | |
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