Scd-1 deficiency promotes the differentiation of CD8+ T effector
Copyright © 2024 Lin, Li, Shan, Gao, Yang, Jiang, Sun, Chen, Liu and Yu..
The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the fatty acid de novo synthesis. Scd-1 converts stearic acid (SA) and palmitic acid (PA) to oleic acid (OA) and palmitoleic acid (PO), respectively. In this study, through a series of experiments, we showed that Scd-1 and its resulting compound, OA, have a substantial impact on the transformation of CD8+ naïve T cells into effector T cells. Inactivation of Scd-1 triggers the specialization of CD8+ T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this. A deeper understanding of lipid metabolism in immune cells and its impact on cell function can lead to new therapeutic approaches for controlling the immune response and improving prognosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in cellular and infection microbiology - 14(2024) vom: 14., Seite 1325390 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Yiwei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.02.2024 Date Revised 23.02.2024 published: Electronic-eCollection GEO: GSE253770 Citation Status MEDLINE |
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| doi: |
10.3389/fcimb.2024.1325390 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368697908 |
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| 520 | |a Copyright © 2024 Lin, Li, Shan, Gao, Yang, Jiang, Sun, Chen, Liu and Yu. | ||
| 520 | |a The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the fatty acid de novo synthesis. Scd-1 converts stearic acid (SA) and palmitic acid (PA) to oleic acid (OA) and palmitoleic acid (PO), respectively. In this study, through a series of experiments, we showed that Scd-1 and its resulting compound, OA, have a substantial impact on the transformation of CD8+ naïve T cells into effector T cells. Inactivation of Scd-1 triggers the specialization of CD8+ T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this. A deeper understanding of lipid metabolism in immune cells and its impact on cell function can lead to new therapeutic approaches for controlling the immune response and improving prognosis | ||
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| 650 | 4 | |a infection | |
| 650 | 4 | |a monounsaturated fatty acid | |
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| 700 | 1 | |a Li, Xushuo |e verfasserin |4 aut | |
| 700 | 1 | |a Shan, Haojie |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yanying |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Linlan |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yuwen |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Fangming |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xiaowei |e verfasserin |4 aut | |
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