Discovery of sesquiterpene from Youngia japonica with antitumor effect
Copyright © 2024 Elsevier B.V. All rights reserved..
Fourteen sesquiterpenes, including one undescribed sesquiterpene lactone, were isolated from Youngia japonica, and their structures were identified by NMR, HRESIMS, ECD and calculated ECD. Cytotoxic activities of all isolates against A549, HeLa, and 4 T1 cell lines were detected by CCK8 assay. Among them, 2 showed obvious cytotoxic activity against A549 cells. Subsequently, the production of ROS, and apoptosis of A549 cells treated with 2 were evaluated. The result showed that 2 distinctly increased the ROS level, and induced the apoptosis of A549 cells. Further anticancer mechanism studies showed that 2 increased the expression of cleaved caspase 3. Taken together, our results demonstrated that 2 might become potential leading compounds for the treatment of lung cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:174 |
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| Enthalten in: |
Fitoterapia - 174(2024) vom: 30. März, Seite 105869 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ye, Xian-Sheng [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2024.105869 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Fourteen sesquiterpenes, including one undescribed sesquiterpene lactone, were isolated from Youngia japonica, and their structures were identified by NMR, HRESIMS, ECD and calculated ECD. Cytotoxic activities of all isolates against A549, HeLa, and 4 T1 cell lines were detected by CCK8 assay. Among them, 2 showed obvious cytotoxic activity against A549 cells. Subsequently, the production of ROS, and apoptosis of A549 cells treated with 2 were evaluated. The result showed that 2 distinctly increased the ROS level, and induced the apoptosis of A549 cells. Further anticancer mechanism studies showed that 2 increased the expression of cleaved caspase 3. Taken together, our results demonstrated that 2 might become potential leading compounds for the treatment of lung cancer | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Cytotoxic activity | |
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| 650 | 4 | |a Sesquiterpene | |
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| 700 | 1 | |a Gui, Yu-Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Shu-Xiu |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Yi-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Hai-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Bin-Lian |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Xi-Ji |e verfasserin |4 aut | |
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