Instant tough adhesion of polymer networks
Generating strong rapid adhesion between hydrogels has the potential to advance the capabilities of modern medicine and surgery. Current hydrogel adhesion technologies rely primarily on liquid-based diffusion mechanisms and the formation of covalent bonds, requiring prolonged time to generate adhesion. Here, we present a simple and versatile strategy using dry chitosan polymer films to generate instant adhesion between hydrogel-hydrogel and hydrogel-elastomer surfaces. Using this approach we can achieve extremely high adhesive energies (>3,000 J/m2), which are governed by pH change and non-covalent interactions including H-bonding, Van der Waals forces, and bridging polymer entanglement. Potential examples of biomedical applications are presented, including local tissue cooling, vascular sealing, prevention of surgical adhesions, and prevention of hydrogel dehydration. We expect these findings and the simplicity of this approach to have broad implications for adhesion strategies and hydrogel design.
| Errataetall: |
CommentIn: Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2401480121. - PMID 38381796 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 121(2024), 9 vom: 27. Feb., Seite e2304643121 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Freedman, Benjamin R [VerfasserIn] |
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| Links: |
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| Themen: |
Adhesive |
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| Anmerkungen: |
Date Completed 22.02.2024 Date Revised 04.03.2024 published: Print-Electronic CommentIn: Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2401480121. - PMID 38381796 Citation Status MEDLINE |
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| doi: |
10.1073/pnas.2304643121 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Generating strong rapid adhesion between hydrogels has the potential to advance the capabilities of modern medicine and surgery. Current hydrogel adhesion technologies rely primarily on liquid-based diffusion mechanisms and the formation of covalent bonds, requiring prolonged time to generate adhesion. Here, we present a simple and versatile strategy using dry chitosan polymer films to generate instant adhesion between hydrogel-hydrogel and hydrogel-elastomer surfaces. Using this approach we can achieve extremely high adhesive energies (>3,000 J/m2), which are governed by pH change and non-covalent interactions including H-bonding, Van der Waals forces, and bridging polymer entanglement. Potential examples of biomedical applications are presented, including local tissue cooling, vascular sealing, prevention of surgical adhesions, and prevention of hydrogel dehydration. We expect these findings and the simplicity of this approach to have broad implications for adhesion strategies and hydrogel design | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a bioinspiration | |
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| 650 | 7 | |a Elastomers |2 NLM | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 700 | 1 | |a Cintron Cruz, Juan A |e verfasserin |4 aut | |
| 700 | 1 | |a Kwon, Phoebe |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Jeffers, Haley M |e verfasserin |4 aut | |
| 700 | 1 | |a Kent, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Kyle C |e verfasserin |4 aut | |
| 700 | 1 | |a Weaver, James C |e verfasserin |4 aut | |
| 700 | 1 | |a Mooney, David J |e verfasserin |4 aut | |
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