Symptomatic gallstone disease : Recurrence patterns and risk factors for relapse after first admission, the RELAPSTONE study
© 2024 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology..
BACKGROUND: Delayed cholecystectomy in patients with symptomatic gallstone disease is associated with recurrence. Limited data on the recurrence patterns and the factors that determine them are available.
OBJECTIVE: We aimed to determine the pattern of relapse in each symptomatic gallstone disease (acute pancreatitis, cholecystitis, cholangitis, symptomatic choledocholithiasis, and biliary colic) and determine the associated factors.
METHODS: RELAPSTONE was an international multicenter retrospective cohort study. Patients (n = 3016) from 18 tertiary centers who suffered a first episode of symptomatic gallstone disease from 2018 to 2020 and had not undergone cholecystectomy during admission were included. The main outcome was relapse-free survival. Kaplan-Meier curves were used in the bivariate analysis. Multivariable Cox regression models were used to identify prognostic factors associated with relapses.
RESULTS: Mean age was 76.6 [IQR: 59.7-84.1], and 51% were male. The median follow-up was 5.3 months [IQR 2.1-12.4]. Relapse-free survival was 0.79 (95% CI: 0.77-0.80) at 3 months, 0.71 (95% CI: 0.69-0.73) at 6 months, and 0.63 (95% CI: 0.61-0.65) at 12 months. In multivariable analysis, older age (HR = 0.57; 95% CI: 0.49-0.66), sphincterotomy (HR = 0.58, 95% CI: 0.49-0.68) and higher leukocyte count (HR = 0.79; 95% CI: 0.70-0.90) were independently associated with lower risk of relapse, whereas higher levels of alanine aminotransferase (HR = 1.22; 95% CI: 1.02-1.46) and multiple cholelithiasis (HR = 1.19, 95% CI: 1.05-1.34) were associated with higher relapse rates.
CONCLUSION: The relapse rate is high and different in each symptomatic gallstone disease. Our independent predictors could be useful for prioritizing patients on the waiting list for cholecystectomies.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
United European gastroenterology journal - 12(2024), 3 vom: 25. Apr., Seite 286-298 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
Biliary colic |
|---|
| Anmerkungen: |
Date Completed 16.04.2024 Date Revised 25.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/ueg2.12544 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368669491 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368669491 | ||
| 003 | DE-627 | ||
| 005 | 20240425232927.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240220s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ueg2.12544 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1386.xml |
| 035 | |a (DE-627)NLM368669491 | ||
| 035 | |a (NLM)38376888 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Velamazán, Raúl |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Symptomatic gallstone disease |b Recurrence patterns and risk factors for relapse after first admission, the RELAPSTONE study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.04.2024 | ||
| 500 | |a Date Revised 25.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. | ||
| 520 | |a BACKGROUND: Delayed cholecystectomy in patients with symptomatic gallstone disease is associated with recurrence. Limited data on the recurrence patterns and the factors that determine them are available | ||
| 520 | |a OBJECTIVE: We aimed to determine the pattern of relapse in each symptomatic gallstone disease (acute pancreatitis, cholecystitis, cholangitis, symptomatic choledocholithiasis, and biliary colic) and determine the associated factors | ||
| 520 | |a METHODS: RELAPSTONE was an international multicenter retrospective cohort study. Patients (n = 3016) from 18 tertiary centers who suffered a first episode of symptomatic gallstone disease from 2018 to 2020 and had not undergone cholecystectomy during admission were included. The main outcome was relapse-free survival. Kaplan-Meier curves were used in the bivariate analysis. Multivariable Cox regression models were used to identify prognostic factors associated with relapses | ||
| 520 | |a RESULTS: Mean age was 76.6 [IQR: 59.7-84.1], and 51% were male. The median follow-up was 5.3 months [IQR 2.1-12.4]. Relapse-free survival was 0.79 (95% CI: 0.77-0.80) at 3 months, 0.71 (95% CI: 0.69-0.73) at 6 months, and 0.63 (95% CI: 0.61-0.65) at 12 months. In multivariable analysis, older age (HR = 0.57; 95% CI: 0.49-0.66), sphincterotomy (HR = 0.58, 95% CI: 0.49-0.68) and higher leukocyte count (HR = 0.79; 95% CI: 0.70-0.90) were independently associated with lower risk of relapse, whereas higher levels of alanine aminotransferase (HR = 1.22; 95% CI: 1.02-1.46) and multiple cholelithiasis (HR = 1.19, 95% CI: 1.05-1.34) were associated with higher relapse rates | ||
| 520 | |a CONCLUSION: The relapse rate is high and different in each symptomatic gallstone disease. Our independent predictors could be useful for prioritizing patients on the waiting list for cholecystectomies | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a biliary colic | |
| 650 | 4 | |a biliary pain | |
| 650 | 4 | |a cholangitis | |
| 650 | 4 | |a cholecystectomy | |
| 650 | 4 | |a cholecystitis | |
| 650 | 4 | |a cholelithiasis | |
| 650 | 4 | |a gallstones | |
| 650 | 4 | |a pancreatitis | |
| 650 | 4 | |a recurrences | |
| 650 | 4 | |a relapse | |
| 700 | 1 | |a López-Guillén, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Domínguez, Samuel J |e verfasserin |4 aut | |
| 700 | 1 | |a Abad Baroja, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Oyón, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Arnau, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Belmonte, Lara M |e verfasserin |4 aut | |
| 700 | 1 | |a Tejedor-Tejada, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Zapater, Raul |e verfasserin |4 aut | |
| 700 | 1 | |a Martín-Vicente, Noelia |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Esparcia, Pedro José |e verfasserin |4 aut | |
| 700 | 1 | |a Julián Gomara, Ana Belén |e verfasserin |4 aut | |
| 700 | 1 | |a Sastre Lozano, Violeta |e verfasserin |4 aut | |
| 700 | 1 | |a Manzanares García, Juan José |e verfasserin |4 aut | |
| 700 | 1 | |a Chivato Martín-Falquina, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Andrés Pascual, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Torres Monclus, Nuria |e verfasserin |4 aut | |
| 700 | 1 | |a Zaragoza Velasco, Natividad |e verfasserin |4 aut | |
| 700 | 1 | |a Rojo, Eukene |e verfasserin |4 aut | |
| 700 | 1 | |a Lapeña-Muñoz, Berta |e verfasserin |4 aut | |
| 700 | 1 | |a Flores, Virginia |e verfasserin |4 aut | |
| 700 | 1 | |a Díaz Gómez, Arantxa |e verfasserin |4 aut | |
| 700 | 1 | |a Cañamares-Orbís, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Vinzo Abizanda, Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Marcos Carrasco, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Pardo Grau, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a García-Rayado, Guillermo |e verfasserin |4 aut | |
| 700 | 1 | |a Millastre Bocos, Judith |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia Garcia de Paredes, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Vaamonde Lorenzo, María |e verfasserin |4 aut | |
| 700 | 1 | |a Izagirre Arostegi, Arantzazu |e verfasserin |4 aut | |
| 700 | 1 | |a Lozada-Hernández, Edgard Efrén |e verfasserin |4 aut | |
| 700 | 1 | |a Velarde-Ruiz Velasco, José Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a de-Madaria, Enrique |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t United European gastroenterology journal |d 2013 |g 12(2024), 3 vom: 25. Apr., Seite 286-298 |w (DE-627)NLM237284804 |x 2050-6414 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2024 |g number:3 |g day:25 |g month:04 |g pages:286-298 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/ueg2.12544 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2024 |e 3 |b 25 |c 04 |h 286-298 | ||