Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
PURPOSE: To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA).
METHODS: We included 23 eyes with macular edema associated with non-ischemic CRVO from 22 patients treated with anti-VEGF therapy (median number of injections: 5 [2-9]). Changes in vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ) parameters were measured using WF SS-OCTA. Visual acuity (VA) and central subfield thickness (CST) were also measured.
RESULTS: Median CST decreased significantly from 369 µm (305-531) to 267 µm (243-300, p < 0.001). VD and VSD parameters in 12 × 12 mm images showed significant reductions. For instance, VSD in the whole retina decreased from a median of 13.37 (11.22-13.74) to 11.29 (9.36-12.97, p = 0.013). Additionally, a significant increase in FAZ circularity was found, suggesting improved microvascular integrity. Significant inverse correlations were found between the number of anti-VEGF injections and all VSD and VD parameters on the 12 × 12 mm images (p < 0.05). Notably, the reductions in VSD and VD on 12 × 12 mm angiograms in the deep capillary plexus (DCP) after each injection significantly correlated with increased logMAR VA (worse VA).
CONCLUSION: Anti-VEGF therapy in CRVO patients not only mitigates macular edema but also alters the overall microvascular morphology and functionality as revealed by WF SS-OCTA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - (2024) vom: 20. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Razavi, Peyman [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-VEGF |
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| Anmerkungen: |
Date Revised 20.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s00417-024-06410-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368666174 |
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| 100 | 1 | |a Razavi, Peyman |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion |
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| 520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a PURPOSE: To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA) | ||
| 520 | |a METHODS: We included 23 eyes with macular edema associated with non-ischemic CRVO from 22 patients treated with anti-VEGF therapy (median number of injections: 5 [2-9]). Changes in vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ) parameters were measured using WF SS-OCTA. Visual acuity (VA) and central subfield thickness (CST) were also measured | ||
| 520 | |a RESULTS: Median CST decreased significantly from 369 µm (305-531) to 267 µm (243-300, p < 0.001). VD and VSD parameters in 12 × 12 mm images showed significant reductions. For instance, VSD in the whole retina decreased from a median of 13.37 (11.22-13.74) to 11.29 (9.36-12.97, p = 0.013). Additionally, a significant increase in FAZ circularity was found, suggesting improved microvascular integrity. Significant inverse correlations were found between the number of anti-VEGF injections and all VSD and VD parameters on the 12 × 12 mm images (p < 0.05). Notably, the reductions in VSD and VD on 12 × 12 mm angiograms in the deep capillary plexus (DCP) after each injection significantly correlated with increased logMAR VA (worse VA) | ||
| 520 | |a CONCLUSION: Anti-VEGF therapy in CRVO patients not only mitigates macular edema but also alters the overall microvascular morphology and functionality as revealed by WF SS-OCTA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-VEGF | |
| 650 | 4 | |a Central retinal vein occlusion (CRVO) | |
| 650 | 4 | |a Vascular metrics | |
| 650 | 4 | |a Vessel density | |
| 650 | 4 | |a Wide field OCTA | |
| 700 | 1 | |a Baldwin, Grace |e verfasserin |4 aut | |
| 700 | 1 | |a Garg, Itika |e verfasserin |4 aut | |
| 700 | 1 | |a Velazquez, Luis Martinez |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia, Mauricio |e verfasserin |4 aut | |
| 700 | 1 | |a Gan, Jenny |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Hanna |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Vingopoulos, Filippos |e verfasserin |4 aut | |
| 700 | 1 | |a Husain, Deeba |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Leo A |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Nimesh A |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, John B |e verfasserin |4 aut | |
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