Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
© 2024. The Author(s)..
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
|---|---|
| Enthalten in: |
Communications biology - 7(2024), 1 vom: 19. Feb., Seite 202 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pérez-Jurado, Luis A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 21.02.2024 Date Revised 22.02.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s42003-024-05805-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368644219 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368644219 | ||
| 003 | DE-627 | ||
| 005 | 20240222232715.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240220s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s42003-024-05805-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1302.xml |
| 035 | |a (DE-627)NLM368644219 | ||
| 035 | |a (NLM)38374351 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Pérez-Jurado, Luis A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2 |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.02.2024 | ||
| 500 | |a Date Revised 22.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Cáceres, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Balagué-Dobón, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Esko, Tonu |e verfasserin |4 aut | |
| 700 | 1 | |a López de Heredia, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Quintela, Inés |e verfasserin |4 aut | |
| 700 | 1 | |a Cruz, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Lapunzina, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Carracedo, Ángel |e verfasserin |4 aut | |
| 700 | 0 | |a SCOURGE Cohort Group |e verfasserin |4 aut | |
| 700 | 1 | |a González, Juan R |e verfasserin |4 aut | |
| 700 | 1 | |a Abellán, Javier |e investigator |4 oth | |
| 700 | 1 | |a Acosta-Isaac, René |e investigator |4 oth | |
| 700 | 1 | |a Aguado, Jose María |e investigator |4 oth | |
| 700 | 1 | |a Aguilar, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Aguilera-Albesa, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Ahmadi Sabbagh, Abdolah |e investigator |4 oth | |
| 700 | 1 | |a Alba, Jorge |e investigator |4 oth | |
| 700 | 1 | |a Albu, Sergiu |e investigator |4 oth | |
| 700 | 1 | |a Alcalá-Gallardo, Karla A M |e investigator |4 oth | |
| 700 | 1 | |a Alcoba-Florez, Julia |e investigator |4 oth | |
| 700 | 1 | |a Alcolea Batres, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Algarin-Lara, Holmes Rafael |e investigator |4 oth | |
| 700 | 1 | |a Almadana, Virginia |e investigator |4 oth | |
| 700 | 1 | |a Medeiros, Kelliane A |e investigator |4 oth | |
| 700 | 1 | |a Almeida, Julia |e investigator |4 oth | |
| 700 | 1 | |a Almoguera, Berta |e investigator |4 oth | |
| 700 | 1 | |a Alonso, María R |e investigator |4 oth | |
| 700 | 1 | |a Álvarez, Nuria |e investigator |4 oth | |
| 700 | 1 | |a Álvarez-Sala Walther, Rodolfo |e investigator |4 oth | |
| 700 | 1 | |a Álvarez-Benítez, Yady |e investigator |4 oth | |
| 700 | 1 | |a Álvarez-Navia, Felipe |e investigator |4 oth | |
| 700 | 1 | |a Dos Santos, Katiusse A |e investigator |4 oth | |
| 700 | 1 | |a Andreu-Bernabeu, Álvaro |e investigator |4 oth | |
| 700 | 1 | |a Antonijoan, Maria Rosa |e investigator |4 oth | |
| 700 | 1 | |a Martínez-Aquino, Eleno |e investigator |4 oth | |
| 700 | 1 | |a Arana-Arri, Eunate |e investigator |4 oth | |
| 700 | 1 | |a Aranda, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Arango, Celso |e investigator |4 oth | |
| 700 | 1 | |a Araque, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Araujo, Nathalia K |e investigator |4 oth | |
| 700 | 1 | |a Arcanjo, Ana C |e investigator |4 oth | |
| 700 | 1 | |a Arnaiz, Ana |e investigator |4 oth | |
| 700 | 1 | |a Arnalich Fernández, Francisco |e investigator |4 oth | |
| 700 | 1 | |a Arranz, María J |e investigator |4 oth | |
| 700 | 1 | |a Arribas López, José Ramón |e investigator |4 oth | |
| 700 | 1 | |a Artiga, Maria-Jesús |e investigator |4 oth | |
| 700 | 1 | |a Avello-Malaver, Yubelly |e investigator |4 oth | |
| 700 | 1 | |a Ayuso, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Ballina Martín, Belén |e investigator |4 oth | |
| 700 | 1 | |a Baptista-Rosas, Raúl C |e investigator |4 oth | |
| 700 | 1 | |a Baldion, Ana María |e investigator |4 oth | |
| 700 | 1 | |a Barranco-Díaz, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Barreda-Sánchez, María |e investigator |4 oth | |
| 700 | 1 | |a Barrera-Penagos, Viviana |e investigator |4 oth | |
| 700 | 1 | |a Belhassen-Garcia, Moncef |e investigator |4 oth | |
| 700 | 1 | |a Bernal-Bello, David |e investigator |4 oth | |
| 700 | 1 | |a Bernal, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Bezerra, Joao F |e investigator |4 oth | |
| 700 | 1 | |a Bezerra, Marcos A C |e investigator |4 oth | |
| 700 | 1 | |a Blanca-López, Natalia |e investigator |4 oth | |
| 700 | 1 | |a Blancas, Rafael |e investigator |4 oth | |
| 700 | 1 | |a Boix-Palop, Lucía |e investigator |4 oth | |
| 700 | 1 | |a Borobia, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Bravo, Elsa |e investigator |4 oth | |
| 700 | 1 | |a Brion, María |e investigator |4 oth | |
| 700 | 1 | |a Brochado-Kith, Óscar |e investigator |4 oth | |
| 700 | 1 | |a Brugada, Ramón |e investigator |4 oth | |
| 700 | 1 | |a Bustos, Matilde |e investigator |4 oth | |
| 700 | 1 | |a Cabello, Alfonso |e investigator |4 oth | |
| 700 | 1 | |a Cáceres-Agra, Juan J |e investigator |4 oth | |
| 700 | 1 | |a Calbo, Esther |e investigator |4 oth | |
| 700 | 1 | |a Calderón, Enrique J |e investigator |4 oth | |
| 700 | 1 | |a Camacho, Shirley |e investigator |4 oth | |
| 700 | 1 | |a Ceballos, Francisco C |e investigator |4 oth | |
| 700 | 1 | |a Cañadas, Yolanda |e investigator |4 oth | |
| 700 | 1 | |a Carbonell, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Cardona-Huerta, Servando |e investigator |4 oth | |
| 700 | 1 | |a Sánchez-Carpintero Abad, María |e investigator |4 oth | |
| 700 | 1 | |a Carpio Segura, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Carrillo-Avila, José Antonio |e investigator |4 oth | |
| 700 | 1 | |a Campos, Marcela C |e investigator |4 oth | |
| 700 | 1 | |a Casasnovas, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Castaño, Luis |e investigator |4 oth | |
| 700 | 1 | |a Castaño, Carlos F |e investigator |4 oth | |
| 700 | 1 | |a Castelao, Jose E |e investigator |4 oth | |
| 700 | 1 | |a Castellano Candalija, Aranzazu |e investigator |4 oth | |
| 700 | 1 | |a Castillo, María A |e investigator |4 oth | |
| 700 | 1 | |a Chaves-Santiago, Walter G |e investigator |4 oth | |
| 700 | 1 | |a Chiquillo-Gómez, Sylena |e investigator |4 oth | |
| 700 | 1 | |a Cid-López, Marco A |e investigator |4 oth | |
| 700 | 1 | |a Cienfuegos-Jiménez, Óscar |e investigator |4 oth | |
| 700 | 1 | |a Conde-Vicente, Rosa |e investigator |4 oth | |
| 700 | 1 | |a Cunha, Gabriela C R |e investigator |4 oth | |
| 700 | 1 | |a Cordero-Lorenzana, M Lourdes |e investigator |4 oth | |
| 700 | 1 | |a Corella, Dolores |e investigator |4 oth | |
| 700 | 1 | |a Corrales, Almudena |e investigator |4 oth | |
| 700 | 1 | |a Cortés-Sánchez, Jose L |e investigator |4 oth | |
| 700 | 1 | |a Corton, Marta |e investigator |4 oth | |
| 700 | 1 | |a Souza, Karla S C |e investigator |4 oth | |
| 700 | 1 | |a Silva, Fabiola T C |e investigator |4 oth | |
| 700 | 1 | |a Cuesta, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Tavares, Nathali A C |e investigator |4 oth | |
| 700 | 1 | |a Carvalho, Maria C C |e investigator |4 oth | |
| 700 | 1 | |a Dalmau, David |e investigator |4 oth | |
| 700 | 1 | |a Dantas-Komatsu, Raquel C S |e investigator |4 oth | |
| 700 | 1 | |a Darnaude, M Teresa |e investigator |4 oth | |
| 700 | 1 | |a de Andrés, Raimundo |e investigator |4 oth | |
| 700 | 1 | |a de Juan, Carmen |e investigator |4 oth | |
| 700 | 1 | |a de la Cruz Troca, Juan J |e investigator |4 oth | |
| 700 | 1 | |a de la Horra, Carmen |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Communications biology |d 2018 |g 7(2024), 1 vom: 19. Feb., Seite 202 |w (DE-627)NLM284287245 |x 2399-3642 |7 nnns |
| 773 | 1 | 8 | |g volume:7 |g year:2024 |g number:1 |g day:19 |g month:02 |g pages:202 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s42003-024-05805-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 7 |j 2024 |e 1 |b 19 |c 02 |h 202 | ||