Cancer resistance and metastasis are maintained through oxidative phosphorylation
Copyright © 2024 Elsevier B.V. All rights reserved..
Malignant tumors have increased energy requirements due to growth, differentiation or response to stress. A significant number of studies in recent years have described upregulation of mitochondrial genes responsible for oxidative phosphorylation (OXPHOS) in some tumors. Although OXPHOS is replaced by glycolysis in some tumors (Warburg effect), both processes can occur simultaneously during the evolution of the same malignancies. In particular, chemoresistant and/or cancer stem cells appear to find a way to activate OXPHOS and metastasize. In this paper, we discuss recent work showing upregulation of OXPHOS in chemoresistant tumors and cell models. In addition, we show an inverse correlation of OXPHOS gene expression with the survival time of cancer patients after chemotherapy and discuss combination therapies for resistant tumors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:587 |
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| Enthalten in: |
Cancer letters - 587(2024) vom: 10. März, Seite 216705 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Uslu, Cemile [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer chemoprevention |
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| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.canlet.2024.216705 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368637506 |
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| 520 | |a Malignant tumors have increased energy requirements due to growth, differentiation or response to stress. A significant number of studies in recent years have described upregulation of mitochondrial genes responsible for oxidative phosphorylation (OXPHOS) in some tumors. Although OXPHOS is replaced by glycolysis in some tumors (Warburg effect), both processes can occur simultaneously during the evolution of the same malignancies. In particular, chemoresistant and/or cancer stem cells appear to find a way to activate OXPHOS and metastasize. In this paper, we discuss recent work showing upregulation of OXPHOS in chemoresistant tumors and cell models. In addition, we show an inverse correlation of OXPHOS gene expression with the survival time of cancer patients after chemotherapy and discuss combination therapies for resistant tumors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cancer chemoprevention | |
| 650 | 4 | |a Cancer chemoresistance | |
| 650 | 4 | |a Cancer stem cells | |
| 650 | 4 | |a Drug repurposing | |
| 650 | 4 | |a Mitochondrial respiration | |
| 650 | 4 | |a Oxidative phosphorylation | |
| 650 | 4 | |a Personalized medicine | |
| 650 | 4 | |a Targeted therapy | |
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| 700 | 1 | |a Lyakhovich, Alex |e verfasserin |4 aut | |
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