Arsenite Mediates Selenite Resistance and Reduction in Enterobacter sp. Z1, Thereby Enhancing Bacterial Survival in Selenium Environments
Arsenic (As) is widely present in the environment, and virtually all bacteria possess a conserved ars operon to resist As toxicity. High selenium (Se) concentrations tend to be cytotoxic. Se has an uneven regional distribution and is added to mitigate As contamination in Se-deficient areas. However, the bacterial response to exogenous Se remains poorly understood. Herein, we found that As(III) presence was crucial for Enterobacter sp. Z1 to develop resistance against Se(IV). Se(IV) reduction served as a detoxification mechanism in bacteria, and our results demonstrated an increase in the production of Se nanoparticles (SeNPs) in the presence of As(III). Tandem mass tag proteomics analysis revealed that the induction of As(III) activated the inositol phosphate, butanoyl-CoA/dodecanoyl-CoA, TCA cycle, and tyrosine metabolism pathways, thereby enhancing bacterial metabolism to resist Se(IV). Additionally, arsHRBC, sdr-mdr, purHD, and grxA were activated to participate in the reduction of Se(IV) into SeNPs. Our findings provide innovative perspectives for exploring As-induced Se biotransformation in prokaryotes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
|---|---|
| Enthalten in: |
Environmental science & technology - 58(2024), 9 vom: 05. März, Seite 4204-4213 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lan, Yan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Arsenic |
|---|
| Anmerkungen: |
Date Completed 06.03.2024 Date Revised 06.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1021/acs.est.3c08346 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368632970 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368632970 | ||
| 003 | DE-627 | ||
| 005 | 20240306232935.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240220s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/acs.est.3c08346 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1318.xml |
| 035 | |a (DE-627)NLM368632970 | ||
| 035 | |a (NLM)38373240 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lan, Yan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Arsenite Mediates Selenite Resistance and Reduction in Enterobacter sp. Z1, Thereby Enhancing Bacterial Survival in Selenium Environments |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.03.2024 | ||
| 500 | |a Date Revised 06.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Arsenic (As) is widely present in the environment, and virtually all bacteria possess a conserved ars operon to resist As toxicity. High selenium (Se) concentrations tend to be cytotoxic. Se has an uneven regional distribution and is added to mitigate As contamination in Se-deficient areas. However, the bacterial response to exogenous Se remains poorly understood. Herein, we found that As(III) presence was crucial for Enterobacter sp. Z1 to develop resistance against Se(IV). Se(IV) reduction served as a detoxification mechanism in bacteria, and our results demonstrated an increase in the production of Se nanoparticles (SeNPs) in the presence of As(III). Tandem mass tag proteomics analysis revealed that the induction of As(III) activated the inositol phosphate, butanoyl-CoA/dodecanoyl-CoA, TCA cycle, and tyrosine metabolism pathways, thereby enhancing bacterial metabolism to resist Se(IV). Additionally, arsHRBC, sdr-mdr, purHD, and grxA were activated to participate in the reduction of Se(IV) into SeNPs. Our findings provide innovative perspectives for exploring As-induced Se biotransformation in prokaryotes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Enterobacter | |
| 650 | 4 | |a arsenite | |
| 650 | 4 | |a differentially expressed proteins | |
| 650 | 4 | |a selenite reduction | |
| 650 | 4 | |a selenium nanoparticles | |
| 650 | 7 | |a Selenium |2 NLM | |
| 650 | 7 | |a H6241UJ22B |2 NLM | |
| 650 | 7 | |a Selenious Acid |2 NLM | |
| 650 | 7 | |a F6A27P4Q4R |2 NLM | |
| 650 | 7 | |a arsenite |2 NLM | |
| 650 | 7 | |a N5509X556J |2 NLM | |
| 650 | 7 | |a Arsenites |2 NLM | |
| 650 | 7 | |a Arsenic |2 NLM | |
| 650 | 7 | |a N712M78A8G |2 NLM | |
| 700 | 1 | |a Luo, Xiong |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Gejiao |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Shixue |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Kaixiang |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Environmental science & technology |d 1967 |g 58(2024), 9 vom: 05. März, Seite 4204-4213 |w (DE-627)NLM112374735 |x 1520-5851 |7 nnns |
| 773 | 1 | 8 | |g volume:58 |g year:2024 |g number:9 |g day:05 |g month:03 |g pages:4204-4213 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/acs.est.3c08346 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 58 |j 2024 |e 9 |b 05 |c 03 |h 4204-4213 | ||