In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
The increasing infection and drug resistance frequency has encouraged the exploration of new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion antimicrobial peptide derivative, effectively inhibit the growth of C. albicans. CT-K3K7 killed C. albicans cells in a dose-dependent manner, mainly by damaging the plasma membrane. CT-K3K7 could also disrupt the nucleus and interact with nucleic acid. Moreover, CT-K3K7 induced C. albicans cells necrosis via a reactive oxygen species (ROS)-related pathway. Furthermore, CT-K3K7 inhibited the hyphal and biofilm formation of C. albicans. In the mouse skin subcutaneous infection model, CT-K3K7 significantly prevented skin abscess formation and reduced the number of C. albicans cells recovered from the infection area. Taken together, CT-K3K7 has the potential to be a therapeutic for C. albicans skin infections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Probiotics and antimicrobial proteins - (2024) vom: 19. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Zhongjie [VerfasserIn] |
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| Links: |
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| Themen: |
Antimicrobial peptide |
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| Anmerkungen: |
Date Revised 19.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s12602-024-10233-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The increasing infection and drug resistance frequency has encouraged the exploration of new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion antimicrobial peptide derivative, effectively inhibit the growth of C. albicans. CT-K3K7 killed C. albicans cells in a dose-dependent manner, mainly by damaging the plasma membrane. CT-K3K7 could also disrupt the nucleus and interact with nucleic acid. Moreover, CT-K3K7 induced C. albicans cells necrosis via a reactive oxygen species (ROS)-related pathway. Furthermore, CT-K3K7 inhibited the hyphal and biofilm formation of C. albicans. In the mouse skin subcutaneous infection model, CT-K3K7 significantly prevented skin abscess formation and reduced the number of C. albicans cells recovered from the infection area. Taken together, CT-K3K7 has the potential to be a therapeutic for C. albicans skin infections | ||
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| 700 | 1 | |a Deng, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wenlu |e verfasserin |4 aut | |
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| 700 | 1 | |a Zhao, Lingyu |e verfasserin |4 aut | |
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