SNOT-22 subdomain outcomes following treatment for sinonasal malignancy : A prospective, multicenter study
© 2024 ARS-AAOA, LLC..
BACKGROUND: Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22-item Sinonasal Outcomes Test (SNOT-22) has been shown to improve with treatment. This study aims to characterize SNOT-22 subdomain outcomes in SNM.
METHODS: Patients diagnosed with SNM were prospectively enrolled in a multi-center patient registry. SNOT-22 scores were collected at the time of diagnosis and through the post-treatment period for up to 5 years. Multivariable regression analysis was used to identify drivers of variation in SNOT-22 subdomains.
RESULTS: Note that 234 patients were reviewed, with a mean follow-up of 22 months (3 months-64 months). Rhinologic, psychological, and sleep subdomains significantly improved versus baseline (all p < 0.05). Subanalysis of 40 patients with follow-up at all timepoints showed statistically significant improvement in rhinologic, extra-nasal, psychological, and sleep subdomains, with minimal clinically important difference met between 2 and 5 years in sleep and psychological subdomains. Adjuvant chemoradiation was associated with worse outcomes in rhinologic (adjusted odds ratio (5.22 [1.69-8.66])), extra-nasal (2.21 [0.22-4.17]) and ear/facial (5.53 [2.10-8.91]) subdomains. Pterygopalatine fossa involvement was associated with worse outcomes in rhinologic (3.22 [0.54-5.93]) and ear/facial (2.97 [0.32-5.65]) subdomains. Positive margins (5.74 [2.17-9.29]) and surgical approach-combined versus endoscopic (3.41 [0.78-6.05])-were associated with worse psychological outcomes. Adjuvant radiation (2.28 [0.18-4.40]) was associated with worse sleep outcomes.
CONCLUSIONS: Sinonasal QOL improvements associated with treatment of SNM are driven by rhinologic, extra-nasal, psychological, and sleep subdomains.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
International forum of allergy & rhinology - (2024) vom: 19. Feb. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Grimm, David R [VerfasserIn] |
---|
Links: |
---|
Themen: |
Endoscopic sinus surgery |
---|
Anmerkungen: |
Date Revised 19.02.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1002/alr.23338 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM36862501X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM36862501X | ||
003 | DE-627 | ||
005 | 20240219232237.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240219s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/alr.23338 |2 doi | |
028 | 5 | 2 | |a pubmed24n1299.xml |
035 | |a (DE-627)NLM36862501X | ||
035 | |a (NLM)38372441 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Grimm, David R |e verfasserin |4 aut | |
245 | 1 | 0 | |a SNOT-22 subdomain outcomes following treatment for sinonasal malignancy |b A prospective, multicenter study |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 19.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a © 2024 ARS-AAOA, LLC. | ||
520 | |a BACKGROUND: Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22-item Sinonasal Outcomes Test (SNOT-22) has been shown to improve with treatment. This study aims to characterize SNOT-22 subdomain outcomes in SNM | ||
520 | |a METHODS: Patients diagnosed with SNM were prospectively enrolled in a multi-center patient registry. SNOT-22 scores were collected at the time of diagnosis and through the post-treatment period for up to 5 years. Multivariable regression analysis was used to identify drivers of variation in SNOT-22 subdomains | ||
520 | |a RESULTS: Note that 234 patients were reviewed, with a mean follow-up of 22 months (3 months-64 months). Rhinologic, psychological, and sleep subdomains significantly improved versus baseline (all p < 0.05). Subanalysis of 40 patients with follow-up at all timepoints showed statistically significant improvement in rhinologic, extra-nasal, psychological, and sleep subdomains, with minimal clinically important difference met between 2 and 5 years in sleep and psychological subdomains. Adjuvant chemoradiation was associated with worse outcomes in rhinologic (adjusted odds ratio (5.22 [1.69-8.66])), extra-nasal (2.21 [0.22-4.17]) and ear/facial (5.53 [2.10-8.91]) subdomains. Pterygopalatine fossa involvement was associated with worse outcomes in rhinologic (3.22 [0.54-5.93]) and ear/facial (2.97 [0.32-5.65]) subdomains. Positive margins (5.74 [2.17-9.29]) and surgical approach-combined versus endoscopic (3.41 [0.78-6.05])-were associated with worse psychological outcomes. Adjuvant radiation (2.28 [0.18-4.40]) was associated with worse sleep outcomes | ||
520 | |a CONCLUSIONS: Sinonasal QOL improvements associated with treatment of SNM are driven by rhinologic, extra-nasal, psychological, and sleep subdomains | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a SNOT-22 | |
650 | 4 | |a endoscopic sinus surgery | |
650 | 4 | |a esthesioneuroblastoma | |
650 | 4 | |a quality of life | |
700 | 1 | |a Beswick, Daniel M |e verfasserin |4 aut | |
700 | 1 | |a Maoz, Sabrina L |e verfasserin |4 aut | |
700 | 1 | |a Wang, Eric W |e verfasserin |4 aut | |
700 | 1 | |a Choby, Garret W |e verfasserin |4 aut | |
700 | 1 | |a Kuan, Edward C |e verfasserin |4 aut | |
700 | 1 | |a Chan, Erik P |e verfasserin |4 aut | |
700 | 1 | |a Adappa, Nithin D |e verfasserin |4 aut | |
700 | 1 | |a Geltzeiler, Mathew |e verfasserin |4 aut | |
700 | 1 | |a Getz, Anne E |e verfasserin |4 aut | |
700 | 1 | |a Humphreys, Ian M |e verfasserin |4 aut | |
700 | 1 | |a Le, Christopher H |e verfasserin |4 aut | |
700 | 1 | |a Abuzeid, Waleed M |e verfasserin |4 aut | |
700 | 1 | |a Chang, Eugene H |e verfasserin |4 aut | |
700 | 1 | |a Jafari, Aria |e verfasserin |4 aut | |
700 | 1 | |a Kingdom, Todd T |e verfasserin |4 aut | |
700 | 1 | |a Kohanski, Michael A |e verfasserin |4 aut | |
700 | 1 | |a Lee, Jivianne K |e verfasserin |4 aut | |
700 | 1 | |a Nayak, Jayakar V |e verfasserin |4 aut | |
700 | 1 | |a Palmer, James N |e verfasserin |4 aut | |
700 | 1 | |a Patel, Zara M |e verfasserin |4 aut | |
700 | 1 | |a Pinheiro-Neto, Carlos D |e verfasserin |4 aut | |
700 | 1 | |a Resnick, Adam C |e verfasserin |4 aut | |
700 | 1 | |a Sim, Myung S |e verfasserin |4 aut | |
700 | 1 | |a Smith, Timothy L |e verfasserin |4 aut | |
700 | 1 | |a Snyderman, Carl H |e verfasserin |4 aut | |
700 | 1 | |a John, Maie A |c St |e verfasserin |4 aut | |
700 | 1 | |a Storm, Phillip |e verfasserin |4 aut | |
700 | 1 | |a Suh, Jeffrey D |e verfasserin |4 aut | |
700 | 1 | |a Wang, Marilene B |e verfasserin |4 aut | |
700 | 1 | |a Hwang, Peter H |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International forum of allergy & rhinology |d 2011 |g (2024) vom: 19. Feb. |w (DE-627)NLM209105178 |x 2042-6984 |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:19 |g month:02 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/alr.23338 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 19 |c 02 |