Unsymmetrical thiourea derivatives : synthesis and evaluation as promising antioxidant and enzyme inhibitors
Background: Unsymmetrical thioureas 1-20 were synthesized and then characterized by various spectroscopy techniques such as UV, IR, fast atom bombardment (FAB)-MS, high-resolution FAB-MS, 1H-NMR and 13C-NMR. Methods: Synthetic compounds 1-20 were tested for their ability for antioxidant, lipoxygenase and xanthine oxidase activities. Results: Compounds 1, 2, 9, 12 and 15 exhibited strong antioxidant potential, whereas compounds 1-3, 9, 12, 15 and 19 showed good to moderate lipoxygenase activity. Ten compounds demonstrated moderate xanthine oxidase inhibition. Conclusion: Compound 15 displayed the highest potency among the series, exhibiting good antioxidant, lipoxygenase and xanthine oxidase activities. Theoretical calculations using density functional theory and molecular docking studies supported the experimental findings, indicating the potential of the synthesized compounds as potent antioxidants, lipoxygenases and xanthine oxidase agents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Future medicinal chemistry - 16(2024), 6 vom: 27. Feb., Seite 497-511 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bano, Bilquees [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidant |
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| Anmerkungen: |
Date Completed 27.02.2024 Date Revised 27.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/fmc-2023-0213 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368622703 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Unsymmetrical thioureas 1-20 were synthesized and then characterized by various spectroscopy techniques such as UV, IR, fast atom bombardment (FAB)-MS, high-resolution FAB-MS, 1H-NMR and 13C-NMR. Methods: Synthetic compounds 1-20 were tested for their ability for antioxidant, lipoxygenase and xanthine oxidase activities. Results: Compounds 1, 2, 9, 12 and 15 exhibited strong antioxidant potential, whereas compounds 1-3, 9, 12, 15 and 19 showed good to moderate lipoxygenase activity. Ten compounds demonstrated moderate xanthine oxidase inhibition. Conclusion: Compound 15 displayed the highest potency among the series, exhibiting good antioxidant, lipoxygenase and xanthine oxidase activities. Theoretical calculations using density functional theory and molecular docking studies supported the experimental findings, indicating the potential of the synthesized compounds as potent antioxidants, lipoxygenases and xanthine oxidase agents | ||
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| 700 | 1 | |a Hameed, Shehryar |e verfasserin |4 aut | |
| 700 | 1 | |a Lateef, Mehreen |e verfasserin |4 aut | |
| 700 | 1 | |a Wadood, Abdul |e verfasserin |4 aut | |
| 700 | 1 | |a Shams, Sulaiman |e verfasserin |4 aut | |
| 700 | 1 | |a Hussain, Shafqat |e verfasserin |4 aut | |
| 700 | 1 | |a Ain, Noor Ui |e verfasserin |4 aut | |
| 700 | 1 | |a Perveen, Shahnaz |e verfasserin |4 aut | |
| 700 | 1 | |a Taha, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Khalid Mohammed |e verfasserin |4 aut | |
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