Visible-light-induced catalyst-free reductive coupling of aldehydes, ketones and imines with cyanopyridines
This article introduces a reductive coupling driven by visible-light, facilitating the synthesis of pyridine-substituted alcohols and amines through the reaction of aldehydes, ketones and imines with cyanopyridines. Hantzsch esters serve as reductants in this process, eliminating the need for transition-metals or photosensitizers. The method demonstrates extensive compatibility and finds utility in the late-stage functionalization of both natural and pharmaceutical products, offering a sustainable pathway for the diversification of chemical compounds.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 60(2024), 21 vom: 07. März, Seite 2926-2929 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zou, Xiaoting [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 07.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d4cc00044g |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368622428 |
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| 245 | 1 | 0 | |a Visible-light-induced catalyst-free reductive coupling of aldehydes, ketones and imines with cyanopyridines |
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| 520 | |a This article introduces a reductive coupling driven by visible-light, facilitating the synthesis of pyridine-substituted alcohols and amines through the reaction of aldehydes, ketones and imines with cyanopyridines. Hantzsch esters serve as reductants in this process, eliminating the need for transition-metals or photosensitizers. The method demonstrates extensive compatibility and finds utility in the late-stage functionalization of both natural and pharmaceutical products, offering a sustainable pathway for the diversification of chemical compounds | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Lang, Yatao |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Xinlong |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Ming-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jiayuan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chao-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Huiying |e verfasserin |4 aut | |
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