Intra-amniotic Candida albicans Infection Treated With Liposomal Amphotericin B With a Successful Neonatal Outcome
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America..
Intra-amniotic infection with Candida species is an uncommon but severe condition with high fetal morbimortality and no established clinical guidelines for its management. We report a Candida albicans intra-amniotic infection diagnosed in a 25-week pregnant woman, successfully treated with high-dose liposomal amphotericin B. Pregnancy was prolonged until 30 weeks, and despite persistently positive Candida cultures in amniotic fluid, a healthy newborn was delivered without evidence of systemic infection. Amphotericin concentration was determined at birth, revealing levels over 30 times higher in mother's and cord blood than in the amniotic fluid, probably explaining the clinical protection despite failure in obtaining fungal clearance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Open forum infectious diseases - 11(2024), 2 vom: 30. Feb., Seite ofae047 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gutiérrez, Norma Urbano [VerfasserIn] |
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| Links: |
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| Themen: |
Candida albicans |
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| Anmerkungen: |
Date Revised 20.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1093/ofid/ofae047 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368603504 |
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| 520 | |a Intra-amniotic infection with Candida species is an uncommon but severe condition with high fetal morbimortality and no established clinical guidelines for its management. We report a Candida albicans intra-amniotic infection diagnosed in a 25-week pregnant woman, successfully treated with high-dose liposomal amphotericin B. Pregnancy was prolonged until 30 weeks, and despite persistently positive Candida cultures in amniotic fluid, a healthy newborn was delivered without evidence of systemic infection. Amphotericin concentration was determined at birth, revealing levels over 30 times higher in mother's and cord blood than in the amniotic fluid, probably explaining the clinical protection despite failure in obtaining fungal clearance | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Candida albicans | |
| 650 | 4 | |a cervical insufficiency | |
| 650 | 4 | |a chorioamnionitis | |
| 650 | 4 | |a fungal chorioamnionitis | |
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| 700 | 1 | |a Vergara López, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Bustos, Camila Álvarez |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Cristian Contreras |e verfasserin |4 aut | |
| 700 | 1 | |a Carvajal, Jorge A |e verfasserin |4 aut | |
| 700 | 1 | |a Severino, Nicolás |e verfasserin |4 aut | |
| 700 | 1 | |a Giordano, Ady |e verfasserin |4 aut | |
| 700 | 1 | |a Baquedano, Soledad Urzúa |e verfasserin |4 aut | |
| 700 | 1 | |a Feuerhake, Teo |e verfasserin |4 aut | |
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| 700 | 1 | |a Balcells, María Elvira |e verfasserin |4 aut | |
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