Gelatin/O-carboxymethyl chitosan injectable self-healing hydrogels for ibuprofen and naproxen dual release
Copyright © 2024 Elsevier B.V. All rights reserved..
Recently, a significantly greater clinical benefit has been reported with a combination of glucosamine sulfate and nonsteroidal anti-inflammatory drugs (NSAIDs) compared to either treatment alone for the growing osteoarthritis (OA) disease. So, this study introduces hydrogels using O-carboxymethyl chitosan (O-CMC, structurally akin glucosamine glycan), and Gelatin type A (GA) in a 1:2 ratio with β-glycerophosphate (βGPh) at varying percentages (5 %, 12.5 %, and 15 %). We show that hydrogel properties, adaptable for drug delivery or tissue engineering, can be fine-tuned based on OCMC:βGPh ratio. CMC/GA/βGPh-12.5 exhibited a swelling rate of 189 %, compressive stress of 164 kPa, and compressive modulus of 3.4 kPa. The self-healing hydrogel also exhibited excellent injectability through a 21-gauge needle, requiring only 5 N of force. Ibuprofen and Naproxen release from CMC/GA/βGPh-12.5 and CMC/GA/βGPh-15 of designed dimensions (bi-layer structures of different diameter and height) were measured, and drug release kinetics were estimated using mathematical equations (MATLAB and polyfit program). CMC/GA/βGPh-12.5 demonstrated significant antibacterial effects against E. coli and S. aureus, a high cell survival rate of 89 % against L929 fibroblasts, and strong cell adhesion, all indicating biocompatibility. These findings underscore potential of these hydrogels as promising candidates for treating inflammatory diseases such as osteoarthritis.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:263 |
---|---|
Enthalten in: |
International journal of biological macromolecules - 263(2024), Pt 1 vom: 25. März, Seite 130266 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mohseni, Mahshad [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 27.03.2024 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.ijbiomac.2024.130266 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368590399 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368590399 | ||
003 | DE-627 | ||
005 | 20240327235834.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240219s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.ijbiomac.2024.130266 |2 doi | |
028 | 5 | 2 | |a pubmed24n1351.xml |
035 | |a (DE-627)NLM368590399 | ||
035 | |a (NLM)38368982 | ||
035 | |a (PII)S0141-8130(24)01069-9 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Mohseni, Mahshad |e verfasserin |4 aut | |
245 | 1 | 0 | |a Gelatin/O-carboxymethyl chitosan injectable self-healing hydrogels for ibuprofen and naproxen dual release |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.03.2024 | ||
500 | |a Date Revised 27.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
520 | |a Recently, a significantly greater clinical benefit has been reported with a combination of glucosamine sulfate and nonsteroidal anti-inflammatory drugs (NSAIDs) compared to either treatment alone for the growing osteoarthritis (OA) disease. So, this study introduces hydrogels using O-carboxymethyl chitosan (O-CMC, structurally akin glucosamine glycan), and Gelatin type A (GA) in a 1:2 ratio with β-glycerophosphate (βGPh) at varying percentages (5 %, 12.5 %, and 15 %). We show that hydrogel properties, adaptable for drug delivery or tissue engineering, can be fine-tuned based on OCMC:βGPh ratio. CMC/GA/βGPh-12.5 exhibited a swelling rate of 189 %, compressive stress of 164 kPa, and compressive modulus of 3.4 kPa. The self-healing hydrogel also exhibited excellent injectability through a 21-gauge needle, requiring only 5 N of force. Ibuprofen and Naproxen release from CMC/GA/βGPh-12.5 and CMC/GA/βGPh-15 of designed dimensions (bi-layer structures of different diameter and height) were measured, and drug release kinetics were estimated using mathematical equations (MATLAB and polyfit program). CMC/GA/βGPh-12.5 demonstrated significant antibacterial effects against E. coli and S. aureus, a high cell survival rate of 89 % against L929 fibroblasts, and strong cell adhesion, all indicating biocompatibility. These findings underscore potential of these hydrogels as promising candidates for treating inflammatory diseases such as osteoarthritis | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Dual drug release | |
650 | 4 | |a Injectable property | |
650 | 4 | |a O-carboxymethyl chitosan | |
650 | 4 | |a Self-healing hydrogel | |
650 | 7 | |a O-carboxymethylchitosan |2 NLM | |
650 | 7 | |a Ibuprofen |2 NLM | |
650 | 7 | |a WK2XYI10QM |2 NLM | |
650 | 7 | |a Naproxen |2 NLM | |
650 | 7 | |a 57Y76R9ATQ |2 NLM | |
650 | 7 | |a Gelatin |2 NLM | |
650 | 7 | |a 9000-70-8 |2 NLM | |
650 | 7 | |a Hydrogels |2 NLM | |
650 | 7 | |a Chitosan |2 NLM | |
650 | 7 | |a 9012-76-4 |2 NLM | |
650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
700 | 1 | |a Shokrollahi, Parvin |e verfasserin |4 aut | |
700 | 1 | |a Barzin, Jalal |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International journal of biological macromolecules |d 1992 |g 263(2024), Pt 1 vom: 25. März, Seite 130266 |w (DE-627)NLM012627356 |x 1879-0003 |7 nnns |
773 | 1 | 8 | |g volume:263 |g year:2024 |g number:Pt 1 |g day:25 |g month:03 |g pages:130266 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijbiomac.2024.130266 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 263 |j 2024 |e Pt 1 |b 25 |c 03 |h 130266 |