Extramammary Paget's Disease of the scrotal and penile : A case report and review of the literature
The Author(s). Published by S. Karger AG, Basel..
INTRODUCTION: Extramammary Paget's Disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, clinical and pathological characteristics are not very clear. There is controversial regarding surgical margin width to decrease the high recurrence rate. This paper aims to report the case and review the literature of Extramammary Paget's Disease of scrotum and penis.
CASE PRESENTATION: We presented the case of a 74-year-old male patient with the patchy erythema and pruritus in the perineum who was admitted to our department. Biopsy of the large plaque revealed Paget disease. Under the condition of ensuring negative surgical margins by rapid frozen pathology, a wide local excision of the lesion, bilateral orchiectomy and adnexectomy were performed on the patient. Pathology revealed that many scattered vacuolated Paget cells were observed in the epidermal layer, and the diagnosis was Paget's disease of the scrotum and penis. The 2cm outside the skin lesion was used as the initial surgical margin and free skin flap transplantation was used to repair the surgical wound. The patient recovered well and was discharged one week after surgery.
CONCLUSION: Currently, histopathologic biopsy is the most important diagnostic method for EMPD. Once confirmed, for patients eligible for surgical intervention, wide local excision of the lesion and rapid intraoperative frozen pathological examination should be performed as soon as possible. The skin flap transplantation is the first choice for the repair of large-scale wound after surgery.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Urologia internationalis - (2024) vom: 17. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Xunguo [VerfasserIn] |
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Date Revised 18.04.2024 published: Print-Electronic ErratumIn: Urol Int. 2024 Apr 18;:1. - PMID 38636470 Citation Status Publisher |
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| doi: |
10.1159/000536654 |
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| Förderinstitution / Projekttitel: |
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NLM36858934X |
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| 100 | 1 | |a Yang, Xunguo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Extramammary Paget's Disease of the scrotal and penile |b A case report and review of the literature |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Urol Int. 2024 Apr 18;:1. - PMID 38636470 | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a The Author(s). Published by S. Karger AG, Basel. | ||
| 520 | |a INTRODUCTION: Extramammary Paget's Disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, clinical and pathological characteristics are not very clear. There is controversial regarding surgical margin width to decrease the high recurrence rate. This paper aims to report the case and review the literature of Extramammary Paget's Disease of scrotum and penis | ||
| 520 | |a CASE PRESENTATION: We presented the case of a 74-year-old male patient with the patchy erythema and pruritus in the perineum who was admitted to our department. Biopsy of the large plaque revealed Paget disease. Under the condition of ensuring negative surgical margins by rapid frozen pathology, a wide local excision of the lesion, bilateral orchiectomy and adnexectomy were performed on the patient. Pathology revealed that many scattered vacuolated Paget cells were observed in the epidermal layer, and the diagnosis was Paget's disease of the scrotum and penis. The 2cm outside the skin lesion was used as the initial surgical margin and free skin flap transplantation was used to repair the surgical wound. The patient recovered well and was discharged one week after surgery | ||
| 520 | |a CONCLUSION: Currently, histopathologic biopsy is the most important diagnostic method for EMPD. Once confirmed, for patients eligible for surgical intervention, wide local excision of the lesion and rapid intraoperative frozen pathological examination should be performed as soon as possible. The skin flap transplantation is the first choice for the repair of large-scale wound after surgery | ||
| 650 | 4 | |a Case Reports | |
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| 700 | 1 | |a Wang, Xingqi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Daoming |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Yubin |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Jihong |e verfasserin |4 aut | |
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