Acute effects of military aircraft noise on sedative and analgesic drug administrations in psychiatric patients : A case-time series analysis
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Existing evidence suggests that psychiatric patients are highly noise sensitive, and that noise exposure increases the risk for adverse mental health outcomes, such as psychiatric hospitalizations and even suicide. To investigate acute effects of noise in this vulnerable population, we assessed short-term associations between fighter jet noise and on-demand sedative and analgesic drug administrations in a psychiatric clinic located close to a military airfield in Switzerland.
METHODS: We applied a case time series analysis with an hourly time resolution using distributed-lag models. Analysis was adjusted for long-term and seasonal trends, day of week, time of day, time-varying weather conditions and the week of stay. Noise exposure (hourly A-weighted equivalent continuous sound pressure levels (LAeq)) was modelled using detailed flight plans and noise footprints for different fighter jet and route combinations. Outcome data were available from the clinic's records.
OUTCOMES: During the study period (06/2016-12/2021), 23,486 flights occurred. 5,968 clinical stays with a median length of 41 days (IQR: 28d, 50d) were recorded. The odds ratio (OR) for medication administration over the lag period of 3 hours after exposure was 1.016 (95 %CI: 1.006, 1.026) per 10 dB LAeq for sedatives and 1.032 (95 %CI: 1.016, 1.048) per 10 dB for analgesics. Effects were larger in multimorbid patients.
INTERPRETATION: Case time series analysis is a novel method to investigate transient associations in observational data while minimizing risk of bias. Using an objectively recorded outcome measure, our results demonstrate that psychiatric patients are a vulnerable population, in which noise exposure can lead to symptom exacerbations and adverse events.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:185 |
|---|---|
| Enthalten in: |
Environment international - 185(2024) vom: 25. März, Seite 108501 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wicki, Benedikt [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Aircraft Noise |
|---|
| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.envint.2024.108501 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368587835 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368587835 | ||
| 003 | DE-627 | ||
| 005 | 20240326235444.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240219s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.envint.2024.108501 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1348.xml |
| 035 | |a (DE-627)NLM368587835 | ||
| 035 | |a (NLM)38368719 | ||
| 035 | |a (PII)S0160-4120(24)00087-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wicki, Benedikt |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute effects of military aircraft noise on sedative and analgesic drug administrations in psychiatric patients |b A case-time series analysis |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.03.2024 | ||
| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: Existing evidence suggests that psychiatric patients are highly noise sensitive, and that noise exposure increases the risk for adverse mental health outcomes, such as psychiatric hospitalizations and even suicide. To investigate acute effects of noise in this vulnerable population, we assessed short-term associations between fighter jet noise and on-demand sedative and analgesic drug administrations in a psychiatric clinic located close to a military airfield in Switzerland | ||
| 520 | |a METHODS: We applied a case time series analysis with an hourly time resolution using distributed-lag models. Analysis was adjusted for long-term and seasonal trends, day of week, time of day, time-varying weather conditions and the week of stay. Noise exposure (hourly A-weighted equivalent continuous sound pressure levels (LAeq)) was modelled using detailed flight plans and noise footprints for different fighter jet and route combinations. Outcome data were available from the clinic's records | ||
| 520 | |a OUTCOMES: During the study period (06/2016-12/2021), 23,486 flights occurred. 5,968 clinical stays with a median length of 41 days (IQR: 28d, 50d) were recorded. The odds ratio (OR) for medication administration over the lag period of 3 hours after exposure was 1.016 (95 %CI: 1.006, 1.026) per 10 dB LAeq for sedatives and 1.032 (95 %CI: 1.016, 1.048) per 10 dB for analgesics. Effects were larger in multimorbid patients | ||
| 520 | |a INTERPRETATION: Case time series analysis is a novel method to investigate transient associations in observational data while minimizing risk of bias. Using an objectively recorded outcome measure, our results demonstrate that psychiatric patients are a vulnerable population, in which noise exposure can lead to symptom exacerbations and adverse events | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aircraft Noise | |
| 650 | 4 | |a Case Time Series | |
| 650 | 4 | |a Medication | |
| 650 | 4 | |a Mental Health | |
| 650 | 4 | |a Psychiatry | |
| 650 | 7 | |a Analgesics |2 NLM | |
| 700 | 1 | |a Vienneau, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Schäffer, Beat |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Thomas J |e verfasserin |4 aut | |
| 700 | 1 | |a Raub, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Widrig, Jonin |e verfasserin |4 aut | |
| 700 | 1 | |a Pervilhac, Charlotte |e verfasserin |4 aut | |
| 700 | 1 | |a Röösli, Martin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Environment international |d 1994 |g 185(2024) vom: 25. März, Seite 108501 |w (DE-627)NLM077828615 |x 1873-6750 |7 nnns |
| 773 | 1 | 8 | |g volume:185 |g year:2024 |g day:25 |g month:03 |g pages:108501 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.envint.2024.108501 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 185 |j 2024 |b 25 |c 03 |h 108501 | ||