Cortical volume abnormalities in schizophrenia : Correlations with symptoms and cognitive impairment
Copyright © 2024 Elsevier B.V. All rights reserved..
BACKGROUND: Schizophrenic symptoms are known to segregate into reality distortion, negative and disorganization syndromes, but the correlates of these syndromes with regional brain structural change are not well established. Cognitive impairment is a further clinical feature of schizophrenia, whose brain structural correlates are the subject of conflicting findings.
METHODS: 165 patients with schizophrenia were rated for symptoms using the PANSS, and cognitive impairment was indexed by estimated premorbid-current IQ discrepancy. Cortical volume was measured using surface-based morphometry in the patients and in 50 healthy controls. Correlations between clinical and cognitive measures and cortical volume were examined using whole-brain FreeSurfer tools.
RESULTS: No clusters of volume reduction were seen associated with reality distortion or disorganization. Negative symptom scores showed a significant inverse correlation with volume in a small cluster in the left medial orbitofrontal gyrus. Larger estimated premorbid-current IQ discrepancies were associated with clusters of reduced cortical volume in the left precentral gyrus and the left temporal lobe. The cluster of association with negative symptoms disappeared when estimated premorbid-current IQ discrepancy was controlled for.
CONCLUSIONS: This study does not provide support for an association between brain structural abnormality and reality distortion or disorganization syndromes in schizophrenia. The cluster of volume reduction found in the left medial orbitofrontal cortex correlated with negative symptoms may have reflected the association between this class of symptoms and cognitive impairment. The study adds to existing findings of an association between cognitive impairment and brain structural changes in the disorder.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:266 |
|---|---|
| Enthalten in: |
Schizophrenia research - 266(2024) vom: 15. März, Seite 50-57 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
García-León, María Ángeles [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Brain morphometry |
|---|
| Anmerkungen: |
Date Completed 20.03.2024 Date Revised 20.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.schres.2024.01.031 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368587703 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368587703 | ||
| 003 | DE-627 | ||
| 005 | 20240320234250.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240219s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.schres.2024.01.031 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1337.xml |
| 035 | |a (DE-627)NLM368587703 | ||
| 035 | |a (NLM)38368705 | ||
| 035 | |a (PII)S0920-9964(24)00031-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a García-León, María Ángeles |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cortical volume abnormalities in schizophrenia |b Correlations with symptoms and cognitive impairment |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.03.2024 | ||
| 500 | |a Date Revised 20.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Schizophrenic symptoms are known to segregate into reality distortion, negative and disorganization syndromes, but the correlates of these syndromes with regional brain structural change are not well established. Cognitive impairment is a further clinical feature of schizophrenia, whose brain structural correlates are the subject of conflicting findings | ||
| 520 | |a METHODS: 165 patients with schizophrenia were rated for symptoms using the PANSS, and cognitive impairment was indexed by estimated premorbid-current IQ discrepancy. Cortical volume was measured using surface-based morphometry in the patients and in 50 healthy controls. Correlations between clinical and cognitive measures and cortical volume were examined using whole-brain FreeSurfer tools | ||
| 520 | |a RESULTS: No clusters of volume reduction were seen associated with reality distortion or disorganization. Negative symptom scores showed a significant inverse correlation with volume in a small cluster in the left medial orbitofrontal gyrus. Larger estimated premorbid-current IQ discrepancies were associated with clusters of reduced cortical volume in the left precentral gyrus and the left temporal lobe. The cluster of association with negative symptoms disappeared when estimated premorbid-current IQ discrepancy was controlled for | ||
| 520 | |a CONCLUSIONS: This study does not provide support for an association between brain structural abnormality and reality distortion or disorganization syndromes in schizophrenia. The cluster of volume reduction found in the left medial orbitofrontal cortex correlated with negative symptoms may have reflected the association between this class of symptoms and cognitive impairment. The study adds to existing findings of an association between cognitive impairment and brain structural changes in the disorder | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Brain morphometry | |
| 650 | 4 | |a Cognitive decline | |
| 650 | 4 | |a Disorganization | |
| 650 | 4 | |a Negative syndrome | |
| 650 | 4 | |a Positive syndrome | |
| 650 | 4 | |a Schizophrenia | |
| 700 | 1 | |a Fuentes-Claramonte, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Soler-Vidal, Joan |e verfasserin |4 aut | |
| 700 | 1 | |a Ramiro-Sousa, Nuria |e verfasserin |4 aut | |
| 700 | 1 | |a Salgado-Pineda, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Salavert, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Torres, Llanos |e verfasserin |4 aut | |
| 700 | 1 | |a Guerrero-Pedraza, Amalia |e verfasserin |4 aut | |
| 700 | 1 | |a Tristany, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Karuk, Andriana |e verfasserin |4 aut | |
| 700 | 1 | |a Barbosa, Lucila |e verfasserin |4 aut | |
| 700 | 1 | |a Del Olmo-Encabo, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Canut-Altemir, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Munuera, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Sarró, Salvador |e verfasserin |4 aut | |
| 700 | 1 | |a Salvador, Raymond |e verfasserin |4 aut | |
| 700 | 1 | |a McKenna, Peter J |e verfasserin |4 aut | |
| 700 | 1 | |a Pomarol-Clotet, Edith |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Schizophrenia research |d 1989 |g 266(2024) vom: 15. März, Seite 50-57 |w (DE-627)NLM013111655 |x 1573-2509 |7 nnns |
| 773 | 1 | 8 | |g volume:266 |g year:2024 |g day:15 |g month:03 |g pages:50-57 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.schres.2024.01.031 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 266 |j 2024 |b 15 |c 03 |h 50-57 | ||