Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms : a systematic review of the literature
© 2024 Walter de Gruyter GmbH, Berlin/Boston..
INTRODUCTION: Viral persistence is one of the main hypotheses explaining the presence of post-COVID symptoms. This systematic review investigated the presence of SARS-CoV-2 RNA in plasma, stool, urine, and nasal/oral swab samples in individuals with post-COVID symptomatology.
CONTENT: MEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to November 25th, 2023. Articles investigating the persistence of SARS-CoV-2 RNA in plasma, stool, urine or nasal/oral swab samples in patients with post-COVID symptoms were included. Methodological quality was assessed using the Newcastle-Ottawa Scale or Cochrane's Risk of Bias (Rob) tool.
SUMMARY: From 322 studies identified, six studies met all inclusion criteria. The sample included 678 COVID-19 survivors (52 % female, aged from 29 to 66 years). The methodological quality was moderate in 88 % of the studies (n=5/6). Three papers investigated the presence of SARS-CoV-2 RNA in plasma, three studies in nasal/oral swabs, two studies in stool samples, one in urine and one in saliva. The follow-up was shorter than two months (<60 days after) in 66 % of the studies (n=4/6). The prevalence of SARS-CoV-2 RNA ranged from 5 to 59 % in patients with post-COVID symptoms the first two months after infection, depending on the sample tested, however, SARS-CoV-2 RNA was also identified in COVID-19 survivors without post-COVID symptoms (one study).
OUTLOOK: Available evidence can suggest the presence of persistent SARS-CoV-2 RNA in post-COVID patients in the short term, although the biases within the studies do not permit us to make firm assumptions. The association between post-COVID symptoms and SARS-CoV-2 RNA in the samples tested is also conflicting. The lack of comparative group without post-COVID symptoms limits the generalizability of viral persistence in post-COVID-19 condition.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
---|---|
Enthalten in: |
Clinical chemistry and laboratory medicine - 62(2024), 6 vom: 27. Apr., Seite 1044-1052 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Fernández-de-Las-Peñas, César [VerfasserIn] |
---|
Links: |
---|
Themen: |
Journal Article |
---|
Anmerkungen: |
Date Completed 29.04.2024 Date Revised 29.04.2024 published: Electronic-Print Citation Status MEDLINE |
---|
doi: |
10.1515/cclm-2024-0036 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368570290 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368570290 | ||
003 | DE-627 | ||
005 | 20240430232053.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240218s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1515/cclm-2024-0036 |2 doi | |
028 | 5 | 2 | |a pubmed24n1393.xml |
035 | |a (DE-627)NLM368570290 | ||
035 | |a (NLM)38366966 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Fernández-de-Las-Peñas, César |e verfasserin |4 aut | |
245 | 1 | 0 | |a Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms |b a systematic review of the literature |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 29.04.2024 | ||
500 | |a Date Revised 29.04.2024 | ||
500 | |a published: Electronic-Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024 Walter de Gruyter GmbH, Berlin/Boston. | ||
520 | |a INTRODUCTION: Viral persistence is one of the main hypotheses explaining the presence of post-COVID symptoms. This systematic review investigated the presence of SARS-CoV-2 RNA in plasma, stool, urine, and nasal/oral swab samples in individuals with post-COVID symptomatology | ||
520 | |a CONTENT: MEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to November 25th, 2023. Articles investigating the persistence of SARS-CoV-2 RNA in plasma, stool, urine or nasal/oral swab samples in patients with post-COVID symptoms were included. Methodological quality was assessed using the Newcastle-Ottawa Scale or Cochrane's Risk of Bias (Rob) tool | ||
520 | |a SUMMARY: From 322 studies identified, six studies met all inclusion criteria. The sample included 678 COVID-19 survivors (52 % female, aged from 29 to 66 years). The methodological quality was moderate in 88 % of the studies (n=5/6). Three papers investigated the presence of SARS-CoV-2 RNA in plasma, three studies in nasal/oral swabs, two studies in stool samples, one in urine and one in saliva. The follow-up was shorter than two months (<60 days after) in 66 % of the studies (n=4/6). The prevalence of SARS-CoV-2 RNA ranged from 5 to 59 % in patients with post-COVID symptoms the first two months after infection, depending on the sample tested, however, SARS-CoV-2 RNA was also identified in COVID-19 survivors without post-COVID symptoms (one study) | ||
520 | |a OUTLOOK: Available evidence can suggest the presence of persistent SARS-CoV-2 RNA in post-COVID patients in the short term, although the biases within the studies do not permit us to make firm assumptions. The association between post-COVID symptoms and SARS-CoV-2 RNA in the samples tested is also conflicting. The lack of comparative group without post-COVID symptoms limits the generalizability of viral persistence in post-COVID-19 condition | ||
650 | 4 | |a Systematic Review | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a RNA | |
650 | 4 | |a long-COVID | |
650 | 4 | |a post-COVID-19 | |
650 | 4 | |a review | |
650 | 4 | |a viral persistence | |
650 | 7 | |a RNA, Viral |2 NLM | |
700 | 1 | |a Torres-Macho, Juan |e verfasserin |4 aut | |
700 | 1 | |a Macasaet, Raymart |e verfasserin |4 aut | |
700 | 1 | |a Velasco, Jacqueline Veronica |e verfasserin |4 aut | |
700 | 1 | |a Ver, Abbygail Therese |e verfasserin |4 aut | |
700 | 1 | |a Culasino Carandang, Timothy Hudson David |e verfasserin |4 aut | |
700 | 1 | |a Guerrero, Jonathan Jaime |e verfasserin |4 aut | |
700 | 1 | |a Franco-Moreno, Ana |e verfasserin |4 aut | |
700 | 1 | |a Chung, William |e verfasserin |4 aut | |
700 | 1 | |a Notarte, Kin Israel |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Clinical chemistry and laboratory medicine |d 1998 |g 62(2024), 6 vom: 27. Apr., Seite 1044-1052 |w (DE-627)NLM095304118 |x 1437-4331 |7 nnns |
773 | 1 | 8 | |g volume:62 |g year:2024 |g number:6 |g day:27 |g month:04 |g pages:1044-1052 |
856 | 4 | 0 | |u http://dx.doi.org/10.1515/cclm-2024-0036 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 62 |j 2024 |e 6 |b 27 |c 04 |h 1044-1052 |