Interactive calculator to estimate insulin sensitivity in type 1 diabetes
© 2024 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd..
The gold standard for measuring insulin sensitivity (IS) is the hyperinsulinemic-euglycemic clamp, a time, costly, and labor-intensive research tool. A low insulin sensitivity is associated with a complication-risk in type 1 diabetes. Various formulae using clinical data have been developed and correlated with measured IS in type 1 diabetes. We consolidated multiple formulae into an online calculator (bit.ly/estimated-GDR), enabling comparison of IS and its probability of IS <4.45 mg/kg/min (low) or >6.50 mg/kg/min (high), as measured in a validation set of clamps in 104 adults with type 1 diabetes. Insulin sensitivity calculations using different formulae varied significantly, with correlations (R2 ) ranging 0.005-0.87 with agreement in detecting low and high glucose disposal rates in the range 49-93% and 89-100%, respectively. We demonstrate that although the calculated IS varies between formulae, their interpretation remains consistent. Our free online calculator offers a user-friendly tool for individual IS calculations and also offers efficient batch processing of data for research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of diabetes investigation - (2024) vom: 17. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Januszewski, Andrzej S [VerfasserIn] |
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| Links: |
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| Themen: |
Insulin sensitivity |
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| Anmerkungen: |
Date Revised 17.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1111/jdi.14161 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368569349 |
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| 245 | 1 | 0 | |a Interactive calculator to estimate insulin sensitivity in type 1 diabetes |
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| 500 | |a Date Revised 17.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. | ||
| 520 | |a The gold standard for measuring insulin sensitivity (IS) is the hyperinsulinemic-euglycemic clamp, a time, costly, and labor-intensive research tool. A low insulin sensitivity is associated with a complication-risk in type 1 diabetes. Various formulae using clinical data have been developed and correlated with measured IS in type 1 diabetes. We consolidated multiple formulae into an online calculator (bit.ly/estimated-GDR), enabling comparison of IS and its probability of IS <4.45 mg/kg/min (low) or >6.50 mg/kg/min (high), as measured in a validation set of clamps in 104 adults with type 1 diabetes. Insulin sensitivity calculations using different formulae varied significantly, with correlations (R2 ) ranging 0.005-0.87 with agreement in detecting low and high glucose disposal rates in the range 49-93% and 89-100%, respectively. We demonstrate that although the calculated IS varies between formulae, their interpretation remains consistent. Our free online calculator offers a user-friendly tool for individual IS calculations and also offers efficient batch processing of data for research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Insulin sensitivity | |
| 650 | 4 | |a Online calculator | |
| 650 | 4 | |a Type 1 diabetes | |
| 700 | 1 | |a Niedzwiecki, Pawel |e verfasserin |4 aut | |
| 700 | 1 | |a Sachithanandan, Nirupa |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Glenn M |e verfasserin |4 aut | |
| 700 | 1 | |a O'Neal, David N |e verfasserin |4 aut | |
| 700 | 1 | |a Zozulinska-Ziolkiewicz, Dorota A |e verfasserin |4 aut | |
| 700 | 1 | |a Uruska, Aleksandra A |e verfasserin |4 aut | |
| 700 | 1 | |a Jenkins, Alicia J |e verfasserin |4 aut | |
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