Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
OBJECTIVES: The objective was to evaluate the effects of experimental apical periodontitis on the inflammatory, functional, biochemical, and redox parameters of the parotid and submandibular glands in rats.
MATERIALS AND METHODS: Twenty 12-week-old male Wistar rats were randomly divided into two groups (n = 10): a control group and apical periodontitis group. After 28 days, the saliva was collected for salivary flow rate and biochemistry composition. Both glands were sampled for quantification of the tumor necrosis factor-alpha (TNF-α) and biochemical analyses of redox state.
RESULTS: TNF-α concentrations were higher in both salivary glands adjacent to the periapical lesions in animals with apical periodontitis and also compared to the control group. The apical periodontitis group increased the salivary amylase, chloride, potassium, calcium, and phosphate. The total oxidant capacity increased in the parotid gland adjacent to the periapical lesions in the same rat and compared to the control group. Conversely, the total antioxidant capacity of the parotid glands on both sides in the apical periodontitis group was lower than that in the control group. Furthermore, glutathione peroxidase activity increased in the submandibular gland adjacent to the apical periodontitis group compared to the control group.
CONCLUSIONS: Experimental apical periodontitis alters salivary biochemical composition, in addition to increasing inflammatory marker and inducing local disturbances in the redox state in the parotid and submandibular glands of male rats.
CLINICAL RELEVANCE: Apical periodontitis could exacerbate the decline in oral health by triggering dysfunction in the salivary glands.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Clinical oral investigations - 28(2024), 2 vom: 16. Feb., Seite 154 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vazão, Arieli Raymundo [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidants |
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| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 26.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00784-024-05540-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368561631 |
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| 245 | 1 | 0 | |a Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a OBJECTIVES: The objective was to evaluate the effects of experimental apical periodontitis on the inflammatory, functional, biochemical, and redox parameters of the parotid and submandibular glands in rats | ||
| 520 | |a MATERIALS AND METHODS: Twenty 12-week-old male Wistar rats were randomly divided into two groups (n = 10): a control group and apical periodontitis group. After 28 days, the saliva was collected for salivary flow rate and biochemistry composition. Both glands were sampled for quantification of the tumor necrosis factor-alpha (TNF-α) and biochemical analyses of redox state | ||
| 520 | |a RESULTS: TNF-α concentrations were higher in both salivary glands adjacent to the periapical lesions in animals with apical periodontitis and also compared to the control group. The apical periodontitis group increased the salivary amylase, chloride, potassium, calcium, and phosphate. The total oxidant capacity increased in the parotid gland adjacent to the periapical lesions in the same rat and compared to the control group. Conversely, the total antioxidant capacity of the parotid glands on both sides in the apical periodontitis group was lower than that in the control group. Furthermore, glutathione peroxidase activity increased in the submandibular gland adjacent to the apical periodontitis group compared to the control group | ||
| 520 | |a CONCLUSIONS: Experimental apical periodontitis alters salivary biochemical composition, in addition to increasing inflammatory marker and inducing local disturbances in the redox state in the parotid and submandibular glands of male rats | ||
| 520 | |a CLINICAL RELEVANCE: Apical periodontitis could exacerbate the decline in oral health by triggering dysfunction in the salivary glands | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Apical periodontitis | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Saliva | |
| 650 | 4 | |a Salivary glands | |
| 650 | 4 | |a Salivary proteins and peptides | |
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| 650 | 7 | |a Antioxidants |2 NLM | |
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| 700 | 1 | |a Fiais, Gabriela Alice |e verfasserin |4 aut | |
| 700 | 1 | |a de Freitas, Rayara Nogueira |e verfasserin |4 aut | |
| 700 | 1 | |a Justo, Mariana Pagliusi |e verfasserin |4 aut | |
| 700 | 1 | |a Brito, Victor Gustavo Balera |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Sandra Helena Penha |e verfasserin |4 aut | |
| 700 | 1 | |a Lima, Rafael Rodrigues |e verfasserin |4 aut | |
| 700 | 1 | |a Cintra, Luciano Tavares Ângelo |e verfasserin |4 aut | |
| 700 | 1 | |a Chaves-Neto, Antonio Hernandes |e verfasserin |4 aut | |
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