Continuous Kidney Replacement Therapy and Survival in Children and Young Adults : Findings From the Multinational WE-ROCK Collaborative
Copyright © 2024 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved..
RATIONALE & OBJECTIVE: There are limited studies describing the epidemiology and outcomes in children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival.
STUDY DESIGN: Retrospective multicenter cohort study.
SETTING & PARTICIPANTS: 980 patients aged from birth to 25 years who received CKRT between 2015 and 2021 at 1 of 32 centers in 7 countries participating in WE-ROCK (Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Diseases).
EXPOSURE: CKRT for acute kidney injury or volume overload.
OUTCOMES: Death before intensive care unit (ICU) discharge.
ANALYTICAL APPROACH: Descriptive statistics.
RESULTS: Median age was 8.8 years (IQR, 1.6-15.0), and median weight was 26.8 (IQR, 11.6-55.0) kg. CKRT was initiated a median of 2 (IQR, 1-6) days after ICU admission and lasted a median of 6 (IQR, 3-14) days. The most common CKRT modality was continuous venovenous hemodiafiltration. Citrate anticoagulation was used in 62%, and the internal jugular vein was the most common catheter placement location (66%). 629 participants (64.1%) survived at least until ICU discharge. CKRT dose, filter type, and anticoagulation were similar in those who did and did not survive to ICU discharge. There were apparent practice variations by institutional ICU size.
LIMITATIONS: Retrospective design; limited representation from centers outside the United States.
CONCLUSIONS: In this study of children and young adults receiving CKRT, approximately two thirds survived at least until ICU discharge. Although variations in dialysis mode and dose, catheter size and location, and anticoagulation were observed, survival was not detected to be associated with these parameters.
PLAIN-LANGUAGE SUMMARY: In this large contemporary epidemiological study of children and young adults receiving continuous kidney replacement therapy in the intensive care unit, we observed that two thirds of patients survived at least until ICU discharge. However, patients with comorbidities appeared to have worse outcomes. Compared with previously published reports on continuous kidney replacement therapy practice, we observed greater use of continuous venovenous hemodiafiltration with regional citrate anticoagulation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
American journal of kidney diseases : the official journal of the National Kidney Foundation - (2024) vom: 15. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Starr, Michelle C [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute kidney injury |
|---|
| Anmerkungen: |
Date Revised 10.04.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1053/j.ajkd.2023.12.017 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36855029X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36855029X | ||
| 003 | DE-627 | ||
| 005 | 20240410232527.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240217s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1053/j.ajkd.2023.12.017 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1371.xml |
| 035 | |a (DE-627)NLM36855029X | ||
| 035 | |a (NLM)38364956 | ||
| 035 | |a (PII)S0272-6386(24)00610-3 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Starr, Michelle C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Continuous Kidney Replacement Therapy and Survival in Children and Young Adults |b Findings From the Multinational WE-ROCK Collaborative |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 10.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a RATIONALE & OBJECTIVE: There are limited studies describing the epidemiology and outcomes in children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival | ||
| 520 | |a STUDY DESIGN: Retrospective multicenter cohort study | ||
| 520 | |a SETTING & PARTICIPANTS: 980 patients aged from birth to 25 years who received CKRT between 2015 and 2021 at 1 of 32 centers in 7 countries participating in WE-ROCK (Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Diseases) | ||
| 520 | |a EXPOSURE: CKRT for acute kidney injury or volume overload | ||
| 520 | |a OUTCOMES: Death before intensive care unit (ICU) discharge | ||
| 520 | |a ANALYTICAL APPROACH: Descriptive statistics | ||
| 520 | |a RESULTS: Median age was 8.8 years (IQR, 1.6-15.0), and median weight was 26.8 (IQR, 11.6-55.0) kg. CKRT was initiated a median of 2 (IQR, 1-6) days after ICU admission and lasted a median of 6 (IQR, 3-14) days. The most common CKRT modality was continuous venovenous hemodiafiltration. Citrate anticoagulation was used in 62%, and the internal jugular vein was the most common catheter placement location (66%). 629 participants (64.1%) survived at least until ICU discharge. CKRT dose, filter type, and anticoagulation were similar in those who did and did not survive to ICU discharge. There were apparent practice variations by institutional ICU size | ||
| 520 | |a LIMITATIONS: Retrospective design; limited representation from centers outside the United States | ||
| 520 | |a CONCLUSIONS: In this study of children and young adults receiving CKRT, approximately two thirds survived at least until ICU discharge. Although variations in dialysis mode and dose, catheter size and location, and anticoagulation were observed, survival was not detected to be associated with these parameters | ||
| 520 | |a PLAIN-LANGUAGE SUMMARY: In this large contemporary epidemiological study of children and young adults receiving continuous kidney replacement therapy in the intensive care unit, we observed that two thirds of patients survived at least until ICU discharge. However, patients with comorbidities appeared to have worse outcomes. Compared with previously published reports on continuous kidney replacement therapy practice, we observed greater use of continuous venovenous hemodiafiltration with regional citrate anticoagulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Continuous kidney replacement therapy | |
| 650 | 4 | |a WE-ROCK | |
| 650 | 4 | |a acute kidney injury | |
| 650 | 4 | |a database | |
| 650 | 4 | |a fluid overload | |
| 650 | 4 | |a intensive care unit | |
| 650 | 4 | |a pediatric | |
| 650 | 4 | |a technique | |
| 700 | 1 | |a Gist, Katja M |e verfasserin |4 aut | |
| 700 | 1 | |a Zang, Huaiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Ollberding, Nicholas J |e verfasserin |4 aut | |
| 700 | 1 | |a Balani, Shanthi |e verfasserin |4 aut | |
| 700 | 1 | |a Cappoli, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccia, Eileen |e verfasserin |4 aut | |
| 700 | 1 | |a Joseph, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Kakajiwala, Aadil |e verfasserin |4 aut | |
| 700 | 1 | |a Kessel, Aaron |e verfasserin |4 aut | |
| 700 | 1 | |a Muff-Luett, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Santiago Lozano, María J |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Reynaud, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Solomon, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Slagle, Cara |e verfasserin |4 aut | |
| 700 | 1 | |a Srivastava, Rachana |e verfasserin |4 aut | |
| 700 | 1 | |a Shih, Weiwen V |e verfasserin |4 aut | |
| 700 | 1 | |a Webb, Tennille |e verfasserin |4 aut | |
| 700 | 1 | |a Menon, Shina |e verfasserin |4 aut | |
| 700 | 0 | |a Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) Collaborative |e verfasserin |4 aut | |
| 700 | 1 | |a Ahern, Emily |e investigator |4 oth | |
| 700 | 1 | |a Arikan, Ayse Akcan |e investigator |4 oth | |
| 700 | 1 | |a Alhamoud, Issa |e investigator |4 oth | |
| 700 | 1 | |a Alobaidi, Rashid |e investigator |4 oth | |
| 700 | 1 | |a Anton-Martin, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Barhight, Matthew |e investigator |4 oth | |
| 700 | 1 | |a Basalely, Abby |e investigator |4 oth | |
| 700 | 1 | |a Bigelow, Amee M |e investigator |4 oth | |
| 700 | 1 | |a Bottari, Gabriella |e investigator |4 oth | |
| 700 | 1 | |a Collins, Michaela |e investigator |4 oth | |
| 700 | 1 | |a Colosimo, Denise |e investigator |4 oth | |
| 700 | 1 | |a Cortina, Gerard |e investigator |4 oth | |
| 700 | 1 | |a Damian, Mihaela A |e investigator |4 oth | |
| 700 | 1 | |a Navazo, Sara de la Mata |e investigator |4 oth | |
| 700 | 1 | |a DeAbreu, Gabrielle |e investigator |4 oth | |
| 700 | 1 | |a Deep, Akash |e investigator |4 oth | |
| 700 | 1 | |a Ding, Kathy L |e investigator |4 oth | |
| 700 | 1 | |a Dolan, Kristin J |e investigator |4 oth | |
| 700 | 1 | |a Fernandez Lafever, Sarah N |e investigator |4 oth | |
| 700 | 1 | |a Fuhrman, Dana Y |e investigator |4 oth | |
| 700 | 1 | |a Gelbart, Ben |e investigator |4 oth | |
| 700 | 1 | |a Gorga, Stephen M |e investigator |4 oth | |
| 700 | 1 | |a Guzzi, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Guzzo, Isabella |e investigator |4 oth | |
| 700 | 1 | |a Haga, Taiki |e investigator |4 oth | |
| 700 | 1 | |a Harvey, Elizabeth |e investigator |4 oth | |
| 700 | 1 | |a Hasson, Denise C |e investigator |4 oth | |
| 700 | 1 | |a Hill-Horowitz, Taylor |e investigator |4 oth | |
| 700 | 1 | |a Inthavong, Haleigh |e investigator |4 oth | |
| 700 | 1 | |a Kaddourah, Ahmad |e investigator |4 oth | |
| 700 | 1 | |a Korn, Sarah |e investigator |4 oth | |
| 700 | 1 | |a Krallman, Kelli A |e investigator |4 oth | |
| 700 | 1 | |a Kwiatkowski, David M |e investigator |4 oth | |
| 700 | 1 | |a Lee, Jasmine |e investigator |4 oth | |
| 700 | 1 | |a Lequier, Laurance |e investigator |4 oth | |
| 700 | 1 | |a Kia, Tina Madani |e investigator |4 oth | |
| 700 | 1 | |a Mah, Kenneth E |e investigator |4 oth | |
| 700 | 1 | |a Marinari, Eleonora |e investigator |4 oth | |
| 700 | 1 | |a Martin, Susan D |e investigator |4 oth | |
| 700 | 1 | |a Mohamed, Tahagod H |e investigator |4 oth | |
| 700 | 1 | |a Morgan, Catherine |e investigator |4 oth | |
| 700 | 1 | |a Mottes, Theresa A |e investigator |4 oth | |
| 700 | 1 | |a Namachivayam, Siva |e investigator |4 oth | |
| 700 | 1 | |a Neumayr, Tara M |e investigator |4 oth | |
| 700 | 1 | |a Nhan, Jennifer |e investigator |4 oth | |
| 700 | 1 | |a O'Rourke, Abigail |e investigator |4 oth | |
| 700 | 1 | |a Qutob, Dua |e investigator |4 oth | |
| 700 | 1 | |a Raggi, Valeria |e investigator |4 oth | |
| 700 | 1 | |a Ricci, Zaccaria |e investigator |4 oth | |
| 700 | 1 | |a Rumlow, Zachary A |e investigator |4 oth | |
| 700 | 1 | |a See, Emily |e investigator |4 oth | |
| 700 | 1 | |a Selewski, David T |e investigator |4 oth | |
| 700 | 1 | |a Serpe, Carmela |e investigator |4 oth | |
| 700 | 1 | |a Serratore, Alyssa |e investigator |4 oth | |
| 700 | 1 | |a Shah, Ananya |e investigator |4 oth | |
| 700 | 1 | |a Shin, H Stella |e investigator |4 oth | |
| 700 | 1 | |a Soranno, Danielle E |e investigator |4 oth | |
| 700 | 1 | |a Stanski, Natalja L |e investigator |4 oth | |
| 700 | 1 | |a Stenson, Erin K |e investigator |4 oth | |
| 700 | 1 | |a Strong, Amy E |e investigator |4 oth | |
| 700 | 1 | |a Taylor, Susan A |e investigator |4 oth | |
| 700 | 1 | |a Thadani, Sameer V |e investigator |4 oth | |
| 700 | 1 | |a Uber, Amanda M |e investigator |4 oth | |
| 700 | 1 | |a Van Wyk, Brynna |e investigator |4 oth | |
| 700 | 1 | |a Zangla, Emily E |e investigator |4 oth | |
| 700 | 1 | |a Zappitelli, Michael |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of kidney diseases : the official journal of the National Kidney Foundation |d 1982 |g (2024) vom: 15. Feb. |w (DE-627)NLM012600814 |x 1523-6838 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:15 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1053/j.ajkd.2023.12.017 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 15 |c 02 | ||