Parkinson's disease patients with absence of normal dipping status were more vulnerable to cognitive impairment from the early stages
Copyright © 2024 Elsevier Ltd. All rights reserved..
INTRODUCTION: The objective of this study was to determine the characteristics of cognitive function in Parkinson's disease (PD) patients with different dipping statuses.
METHODS: Consecutive PD patients were recruited for this study. All participants underwent 24-h ambulatory blood pressure monitor (ABPM). Corresponding scales were employed to evaluate both motor and non-motor symptoms. The subjects were categorized into reverse, reduced, normal, and extreme dipping groups based on dipping patterns. Additionally, they were divided into early and non-early stage groups according to the disease duration being more than 5 years.
RESULTS: The proportions of the four dipping groups in the early and non-early stage groups exhibited no significant differences. The Montreal Cognitive Assessment (MoCA) scores in the reverse group were significantly lower than those in the normal dipping group (16.2 ± 5.8 vs 21.1 ± 6.1,P = 0.003). The attention as well as delayed recall scores in the reverse dipping group were significant lower than those in the normal dipping group (P = 0.042; P < 0.001). The multivariate linear regression analysis revealed that absence of normal dipping was an independent risk factor (OR = -2.252; P = 0.027) for MoCA scores for PD patients.
CONCLUSIONS: PD patients with absence of normal dipping status were more vulnerable to cognitive impairment from the early stages of the disease. The 24-h ABPM is recommended for early detection of abnormal dipping status and identification of individuals at risk for cognitive decline.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
|---|---|
| Enthalten in: |
Parkinsonism & related disorders - 121(2024) vom: 15. Apr., Seite 106013 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen, Lanlan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
24-h ambulatory blood pressure monitor |
|---|
| Anmerkungen: |
Date Completed 05.04.2024 Date Revised 05.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.parkreldis.2024.106013 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368546942 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368546942 | ||
| 003 | DE-627 | ||
| 005 | 20240405233555.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240217s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.parkreldis.2024.106013 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1366.xml |
| 035 | |a (DE-627)NLM368546942 | ||
| 035 | |a (NLM)38364621 | ||
| 035 | |a (PII)S1353-8020(24)00025-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen, Lanlan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Parkinson's disease patients with absence of normal dipping status were more vulnerable to cognitive impairment from the early stages |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.04.2024 | ||
| 500 | |a Date Revised 05.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier Ltd. All rights reserved. | ||
| 520 | |a INTRODUCTION: The objective of this study was to determine the characteristics of cognitive function in Parkinson's disease (PD) patients with different dipping statuses | ||
| 520 | |a METHODS: Consecutive PD patients were recruited for this study. All participants underwent 24-h ambulatory blood pressure monitor (ABPM). Corresponding scales were employed to evaluate both motor and non-motor symptoms. The subjects were categorized into reverse, reduced, normal, and extreme dipping groups based on dipping patterns. Additionally, they were divided into early and non-early stage groups according to the disease duration being more than 5 years | ||
| 520 | |a RESULTS: The proportions of the four dipping groups in the early and non-early stage groups exhibited no significant differences. The Montreal Cognitive Assessment (MoCA) scores in the reverse group were significantly lower than those in the normal dipping group (16.2 ± 5.8 vs 21.1 ± 6.1,P = 0.003). The attention as well as delayed recall scores in the reverse dipping group were significant lower than those in the normal dipping group (P = 0.042; P < 0.001). The multivariate linear regression analysis revealed that absence of normal dipping was an independent risk factor (OR = -2.252; P = 0.027) for MoCA scores for PD patients | ||
| 520 | |a CONCLUSIONS: PD patients with absence of normal dipping status were more vulnerable to cognitive impairment from the early stages of the disease. The 24-h ABPM is recommended for early detection of abnormal dipping status and identification of individuals at risk for cognitive decline | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 24-h ambulatory blood pressure monitor | |
| 650 | 4 | |a Cognitive impairment | |
| 650 | 4 | |a Normal dipping | |
| 650 | 4 | |a Parkinson's disease | |
| 650 | 4 | |a Reverse dipping | |
| 700 | 1 | |a Jiang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chenxin |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Tingting |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Cancan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yingzhu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chunfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yao |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Parkinsonism & related disorders |d 1995 |g 121(2024) vom: 15. Apr., Seite 106013 |w (DE-627)NLM094552002 |x 1873-5126 |7 nnns |
| 773 | 1 | 8 | |g volume:121 |g year:2024 |g day:15 |g month:04 |g pages:106013 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.parkreldis.2024.106013 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 121 |j 2024 |b 15 |c 04 |h 106013 | ||