Mechanism of surfactant interactions with feline coronavirus : A physical chemistry perspective
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
HYPOTHESIS: Surfactants are inexpensive chemicals with promising applications in virus inactivation, particularly for enveloped viruses. Yet, the detailed mechanisms by which surfactants deactivate coronaviruses remain underexplored. This study delves into the virucidal mechanisms of various surfactants on Feline Coronavirus (FCoV) and their potential applications against more pathogenic coronaviruses.
EXPERIMENTS: By integrating virucidal activity assays with fluorescence spectroscopy, dynamic light scattering and laser Doppler electrophoresis, alongside liposome permeability experiments, we have analyzed the effects of non-ionic and ionic surfactants on viral activity.
FINDINGS: The non-ionic surfactant octaethylene glycol monodecyl ether (C10EO8) inactivates the virus by disrupting the lipid envelope, whereas ionic surfactants like Sodium Dodecyl Sulfate and Cetylpyridinium Chloride predominantly affect the spike proteins, with their impact on the viral membrane being hampered by kinetic and thermodynamic constraints. FCoV served as a safe model for studying virucidal activity, offering a faster alternative to traditional virucidal assays. The study demonstrates that physicochemical techniques can expedite the screening of virucidal compounds, contributing to the design of effective disinfectant formulations. Our results not only highlight the critical role of surfactant-virus interactions but also contribute to strategic advancements in public health measures for future pandemic containment and the ongoing challenge of antimicrobial resistance.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:662 |
|---|---|
| Enthalten in: |
Journal of colloid and interface science - 662(2024) vom: 15. März, Seite 535-544 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mateos, Helena [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
368GB5141J |
|---|
| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 13.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jcis.2024.02.088 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368545482 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368545482 | ||
| 003 | DE-627 | ||
| 005 | 20240313234342.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240217s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jcis.2024.02.088 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1326.xml |
| 035 | |a (DE-627)NLM368545482 | ||
| 035 | |a (NLM)38364478 | ||
| 035 | |a (PII)S0021-9797(24)00332-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mateos, Helena |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mechanism of surfactant interactions with feline coronavirus |b A physical chemistry perspective |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.03.2024 | ||
| 500 | |a Date Revised 13.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a HYPOTHESIS: Surfactants are inexpensive chemicals with promising applications in virus inactivation, particularly for enveloped viruses. Yet, the detailed mechanisms by which surfactants deactivate coronaviruses remain underexplored. This study delves into the virucidal mechanisms of various surfactants on Feline Coronavirus (FCoV) and their potential applications against more pathogenic coronaviruses | ||
| 520 | |a EXPERIMENTS: By integrating virucidal activity assays with fluorescence spectroscopy, dynamic light scattering and laser Doppler electrophoresis, alongside liposome permeability experiments, we have analyzed the effects of non-ionic and ionic surfactants on viral activity | ||
| 520 | |a FINDINGS: The non-ionic surfactant octaethylene glycol monodecyl ether (C10EO8) inactivates the virus by disrupting the lipid envelope, whereas ionic surfactants like Sodium Dodecyl Sulfate and Cetylpyridinium Chloride predominantly affect the spike proteins, with their impact on the viral membrane being hampered by kinetic and thermodynamic constraints. FCoV served as a safe model for studying virucidal activity, offering a faster alternative to traditional virucidal assays. The study demonstrates that physicochemical techniques can expedite the screening of virucidal compounds, contributing to the design of effective disinfectant formulations. Our results not only highlight the critical role of surfactant-virus interactions but also contribute to strategic advancements in public health measures for future pandemic containment and the ongoing challenge of antimicrobial resistance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dynamic light scattering | |
| 650 | 4 | |a Feline coronavirus | |
| 650 | 4 | |a Membrane permeabilization | |
| 650 | 4 | |a Surfactant–protein interactions | |
| 650 | 4 | |a Virucides | |
| 650 | 7 | |a Surface-Active Agents |2 NLM | |
| 650 | 7 | |a Sodium Dodecyl Sulfate |2 NLM | |
| 650 | 7 | |a 368GB5141J |2 NLM | |
| 700 | 1 | |a Mallardi, Antonia |e verfasserin |4 aut | |
| 700 | 1 | |a Camero, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Lanave, Gianvito |e verfasserin |4 aut | |
| 700 | 1 | |a Catella, Cristiana |e verfasserin |4 aut | |
| 700 | 1 | |a Buonavoglia, Alessio |e verfasserin |4 aut | |
| 700 | 1 | |a De Giglio, Osvalda |e verfasserin |4 aut | |
| 700 | 1 | |a Buonavoglia, Canio |e verfasserin |4 aut | |
| 700 | 1 | |a Palazzo, Gerardo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of colloid and interface science |d 1966 |g 662(2024) vom: 15. März, Seite 535-544 |w (DE-627)NLM041487958 |x 1095-7103 |7 nnns |
| 773 | 1 | 8 | |g volume:662 |g year:2024 |g day:15 |g month:03 |g pages:535-544 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jcis.2024.02.088 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 662 |j 2024 |b 15 |c 03 |h 535-544 | ||