Stimuli-triggered multilayer films in response to temperature and ionic strength changes for controlled favipiravir drug release
© 2024 IOP Publishing Ltd..
The block copolymer micelles and natural biopolymers were utilized to form layer-by-layer (LbL) films via electrostatic interaction, which were able to effectively load and controllably release favipiravir, a potential drug for the treatment of coronavirus epidemic. The LbL films demonstrated reversible swelling/shrinking behavior along with the manipulation of temperature, which could also maintain the integrity in the structure and the morphology. Due to dehydration of environmentally responsive building blocks, the drug release rate from the films was decelerated by elevating environmental temperature and ionic strength. In addition, the pulsed release of favipiravir was observed from the multilayer films under the trigger of temperature, which ensured the precise control in the content of the therapeutic reagents at a desired time point. The nanoparticle-based LbL films could be used for on-demandin vitrorelease of chemotherapeutic reagents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Biomedical materials (Bristol, England) - 19(2024), 3 vom: 05. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xu, Li [VerfasserIn] |
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| Links: |
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| Themen: |
Amides |
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| Anmerkungen: |
Date Completed 06.03.2024 Date Revised 06.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1088/1748-605X/ad2a3b |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368543579 |
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| 520 | |a The block copolymer micelles and natural biopolymers were utilized to form layer-by-layer (LbL) films via electrostatic interaction, which were able to effectively load and controllably release favipiravir, a potential drug for the treatment of coronavirus epidemic. The LbL films demonstrated reversible swelling/shrinking behavior along with the manipulation of temperature, which could also maintain the integrity in the structure and the morphology. Due to dehydration of environmentally responsive building blocks, the drug release rate from the films was decelerated by elevating environmental temperature and ionic strength. In addition, the pulsed release of favipiravir was observed from the multilayer films under the trigger of temperature, which ensured the precise control in the content of the therapeutic reagents at a desired time point. The nanoparticle-based LbL films could be used for on-demandin vitrorelease of chemotherapeutic reagents | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a drug delivery | |
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| 700 | 1 | |a He, Lang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yinzhao |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Tingwei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jianhua |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Zihan |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Xiaochen |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Raymond |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Haifeng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Chunyin |e verfasserin |4 aut | |
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