Corticosteroids and mania : A systematic review

OBJECTIVES: Corticosteroids are widely prescribed for a variety of medical conditions. Accumulating evidence suggests that their use may be associated with adverse psychiatric effects, including mania. In this systematic review, we aim to critically evaluate the existing literature on the association between corticosteroid use and the emergence of mania.

METHODS: We conducted a comprehensive search of major electronic databases (PubMed, Embase, Cochrane Library) for relevant studies published up to the date of the search (12th January 2023). Inclusion criteria involve studies that investigate the association between corticosteroid use and the emergence of mania in adult patients. The primary outcome is the prevalence of (hypo)mania following corticosteroid administration. Secondary outcomes include potential risk factors, dose-response relationships, and differences among various corticosteroid formulations.

RESULTS: The identified studies were subjected to a systematic selection process and data extraction by an independent reviewer. A total of 47 articles met the inclusion criteria for our systematic review.

CONCLUSION: Our findings suggest that mania is a common side-effect of corticosteroid use, particularly in prednisone equivalent doses above 40 mg. These findings hold practical significance for clinicians and provide insights into potential interventions, including careful monitoring, dose adjustments, and consideration of psychotropic medications when managing corticosteroid-induced mania.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:25

Enthalten in:

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 25(2024), 3 vom: 22. März, Seite 161-174

Sprache:

Englisch

Beteiligte Personen:

De Bock, Mathias [VerfasserIn]
Sienaert, Pascal [VerfasserIn]

Links:

Volltext

Themen:

Adrenal Cortex Hormones
Corticosteroids
Journal Article
Mania
Prednisone
Review
Systematic Review
VB0R961HZT

Anmerkungen:

Date Completed 27.03.2024

Date Revised 27.03.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/15622975.2024.2312572

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM368533980