Synthesis of pyrazino[1,2-b]indazoles via cascade cyclization of indazole aldehydes with propargylic amines
An efficient intermolecular annulation of indazole aldehydes with propargylic amines has been developed for the synthesis of pyrazinoindazoles under catalyst- and additive-free conditions. This straightforward methodology was found to feature a wide substrate scope, high atom economy and environmental advantages. The bioactivity results of these new pyrazino[1,2-b]indazoles showed that some of them exhibited significant antifungal activity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Organic & biomolecular chemistry - 22(2024), 11 vom: 13. März, Seite 2226-2230 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Zeng-Hui [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 13.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d4ob00051j |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368533581 |
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| 520 | |a An efficient intermolecular annulation of indazole aldehydes with propargylic amines has been developed for the synthesis of pyrazinoindazoles under catalyst- and additive-free conditions. This straightforward methodology was found to feature a wide substrate scope, high atom economy and environmental advantages. The bioactivity results of these new pyrazino[1,2-b]indazoles showed that some of them exhibited significant antifungal activity | ||
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| 700 | 1 | |a Han, Ben-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jia-Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Xiang-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Cheng-Tao |e verfasserin |4 aut | |
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