Research advances of MAL family members in tumorigenesis and tumor progression (Review)
The myelin and lymphocyte protein (MAL) family is a novel gene family first identified and characterized in 2002. This family is comprised of seven members, including MAL, MAL2, plasmolipin, MALL, myeloid differentiation‑associated marker (MYADM), MYADML2 and CMTM8, which are located on different chromosomes. In addition to exhibiting extensive activity during transcytosis, the MAL family plays a vital role in the neurological, digestive, respiratory, genitourinary and other physiological systems. Furthermore, the intimate association between MAL and the pathogenesis, progression and metastasis of malignancies, attributable to several mechanisms such as DNA methylation has also been elucidated. In the present review, an overview of the structural and functional properties of the MAL family and the latest research findings regarding the relationship between several MAL members and various cancers is provided. Furthermore, the potential clinical and scientific significance of MAL is discussed and directions for future research are summarized.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Molecular medicine reports - 29(2024), 4 vom: 16. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Mengyao [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 25.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3892/mmr.2024.13181 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368530213 |
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| 100 | 1 | |a Li, Mengyao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Research advances of MAL family members in tumorigenesis and tumor progression (Review) |
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| 500 | |a Date Completed 19.02.2024 | ||
| 500 | |a Date Revised 25.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The myelin and lymphocyte protein (MAL) family is a novel gene family first identified and characterized in 2002. This family is comprised of seven members, including MAL, MAL2, plasmolipin, MALL, myeloid differentiation‑associated marker (MYADM), MYADML2 and CMTM8, which are located on different chromosomes. In addition to exhibiting extensive activity during transcytosis, the MAL family plays a vital role in the neurological, digestive, respiratory, genitourinary and other physiological systems. Furthermore, the intimate association between MAL and the pathogenesis, progression and metastasis of malignancies, attributable to several mechanisms such as DNA methylation has also been elucidated. In the present review, an overview of the structural and functional properties of the MAL family and the latest research findings regarding the relationship between several MAL members and various cancers is provided. Furthermore, the potential clinical and scientific significance of MAL is discussed and directions for future research are summarized | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CKLF‑like MARVEL transmembrane domain‑containing 8 | |
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a MAL and related proteins for vesicle formation and membrane link | |
| 650 | 4 | |a myelin and lymphocyte protein | |
| 650 | 4 | |a myeloid differentiation‑associated marker | |
| 650 | 4 | |a plasmolipin | |
| 650 | 4 | |a tumor | |
| 650 | 7 | |a Myelin and Lymphocyte-Associated Proteolipid Proteins |2 NLM | |
| 650 | 7 | |a Proteolipids |2 NLM | |
| 650 | 7 | |a Myelin Proteins |2 NLM | |
| 650 | 7 | |a Proteins |2 NLM | |
| 650 | 7 | |a MAL2 protein, human |2 NLM | |
| 650 | 7 | |a CMTM8 protein, human |2 NLM | |
| 650 | 7 | |a Chemokines |2 NLM | |
| 650 | 7 | |a MARVEL Domain-Containing Proteins |2 NLM | |
| 650 | 7 | |a MYADML2 protein, human |2 NLM | |
| 700 | 1 | |a Du, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xianzhuo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Wence |e verfasserin |4 aut | |
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