A model for N-to-C direction in prebiotic peptide synthesis
Drawing inspiration from the initiating amino acid modification in biosynthetic peptides, we have successfully demonstrated a biomimetic mechanism for N-to-C terminal extension in prebiotic peptide synthesis. This achievement was accomplished by using acetylated amino acid amides as the N-terminal substrate for peptide synthesis and amino acid amides as the C-terminal extension, with the reaction carried out in a dry-wet cycle at 80 °C without requiring any activators. This provides a plausible pathway for the formation of prebiotic peptides.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 60(2024), 20 vom: 05. März, Seite 2748-2751 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Li [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 06.03.2024 Date Revised 06.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d3cc06101a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Drawing inspiration from the initiating amino acid modification in biosynthetic peptides, we have successfully demonstrated a biomimetic mechanism for N-to-C terminal extension in prebiotic peptide synthesis. This achievement was accomplished by using acetylated amino acid amides as the N-terminal substrate for peptide synthesis and amino acid amides as the C-terminal extension, with the reaction carried out in a dry-wet cycle at 80 °C without requiring any activators. This provides a plausible pathway for the formation of prebiotic peptides | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Guo, Xiaofan |e verfasserin |4 aut | |
| 700 | 1 | |a Gan, Dingwei |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yufen |e verfasserin |4 aut | |
| 700 | 1 | |a Ying, Jianxi |e verfasserin |4 aut | |
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