The spatial landscape of T cells in the microenvironment of stage III lung adenocarcinoma
© 2024 The Pathological Society of Great Britain and Ireland..
This study aimed to provide more information for prognostic stratification for patients through an analysis of the T-cell spatial landscape. It involved analyzing stained tissue sections of 80 patients with stage III lung adenocarcinoma (LUAD) using multiplex immunofluorescence and exploring the spatial landscape of T cells and their relationship with prognosis in the center of the tumor (CT) and invasive margin (IM). In this study, multivariate regression suggested that the relative clustering of CT CD4+ conventional T cell (Tconv) to inducible Treg (iTreg), natural regulatory T cell (nTreg) to Tconv, terminal CD8+ T cell (tCD8) to helper T cell (Th), and IM Treg to tCD8 and the relative dispersion of CT nTreg to iTreg, IM nTreg to nTreg were independent risk factors for DFS. Finally, we constructed a spatial immunological score named the GT score, which had stronger prognostic correlation than IMMUNOSCORE® based on CD3/CD8 cell densities. The spatial layout of T cells in the tumor microenvironment and the proposed GT score can reflect the prognosis of patients with stage III LUAD more effectively than T-cell density. The exploration of the T-cell spatial landscape may suggest potential cell-cell interactions and therapeutic targets and better guide clinical decision-making. © 2024 The Pathological Society of Great Britain and Ireland.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:262 |
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Enthalten in: |
The Journal of pathology - 262(2024), 4 vom: 03. Apr., Seite 517-528 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Zeng, Ziqing [VerfasserIn] |
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Links: |
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Themen: |
CD4-positive T lymphocytes |
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Anmerkungen: |
Date Completed 06.03.2024 Date Revised 04.04.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/path.6254 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM368515656 |
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520 | |a This study aimed to provide more information for prognostic stratification for patients through an analysis of the T-cell spatial landscape. It involved analyzing stained tissue sections of 80 patients with stage III lung adenocarcinoma (LUAD) using multiplex immunofluorescence and exploring the spatial landscape of T cells and their relationship with prognosis in the center of the tumor (CT) and invasive margin (IM). In this study, multivariate regression suggested that the relative clustering of CT CD4+ conventional T cell (Tconv) to inducible Treg (iTreg), natural regulatory T cell (nTreg) to Tconv, terminal CD8+ T cell (tCD8) to helper T cell (Th), and IM Treg to tCD8 and the relative dispersion of CT nTreg to iTreg, IM nTreg to nTreg were independent risk factors for DFS. Finally, we constructed a spatial immunological score named the GT score, which had stronger prognostic correlation than IMMUNOSCORE® based on CD3/CD8 cell densities. The spatial layout of T cells in the tumor microenvironment and the proposed GT score can reflect the prognosis of patients with stage III LUAD more effectively than T-cell density. The exploration of the T-cell spatial landscape may suggest potential cell-cell interactions and therapeutic targets and better guide clinical decision-making. © 2024 The Pathological Society of Great Britain and Ireland | ||
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700 | 1 | |a Du, Weijiao |e verfasserin |4 aut | |
700 | 1 | |a Yang, Fan |e verfasserin |4 aut | |
700 | 1 | |a Hui, Zhenzhen |e verfasserin |4 aut | |
700 | 1 | |a Wang, Yunliang |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Peng |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Xiying |e verfasserin |4 aut | |
700 | 1 | |a Yu, Wenwen |e verfasserin |4 aut | |
700 | 1 | |a Ren, Xiubao |e verfasserin |4 aut | |
700 | 1 | |a Wei, Feng |e verfasserin |4 aut | |
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