Cinnamic Acid Ameliorates Acetic Acid-induced Inflammatory Response through Inhibition of TLR-4 in Colitis Rat Model
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Cinnamic acid, an active compound in cinnamon spp., has anti-inflamatory and antioxidant characteristics and is favorable in managing inflammatory bowel diseases.
OBJECTIVE: Evaluate cinnamic acid's effects on colitis in rats.
METHODS: To induce colitis in experimental rats, excluding the sham group, a 4% intrarectal solution of acetic acid was administered. The rats were then given oral doses of cinnamic acid at 30, 45, and 90 mg/kg for two days. The animals were assessed for macroscopic and microscopic changes, and the levels of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO) were measured using Eliza kits. Additionally, real-time PCR was performed to examine the gene level of toll-like receptor 4 (TLR-4) in the colon.
RESULTS: Effective reduction of inflammation in acetic acid-induced colitis was achieved through cinnamic acid at doses of 45 and 90 mg/kg. The decrease was achieved by inhibiting the activities of TNF-α, IL-6, and MPO while downregulating the expression of TLR-4. It is important to note that macroscopic and microscopic evaluations were significant in determining the effectiveness of cinnamic acid in reducing inflammation.
CONCLUSION: Downregulation of inflammatory cytokines and TLR-4 expression may contribute to cinnamic acid's anti-inflammatory effect.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Anti-inflammatory & anti-allergy agents in medicinal chemistry - (2024) vom: 29. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rezaei, Zahra [VerfasserIn] |
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| Links: |
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| Themen: |
Cinnamic acid; Inflammatory bowel disease (IBD); Interleukin-6 (IL-6); Myeloperoxidase (MPO); Toll-like recep-tor-4 (TLR-4); Tumor necrosis factor-alpha (TNF-α). |
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| Anmerkungen: |
Date Revised 16.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0118715230278980231212103709 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36851434X |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Cinnamic acid, an active compound in cinnamon spp., has anti-inflamatory and antioxidant characteristics and is favorable in managing inflammatory bowel diseases | ||
| 520 | |a OBJECTIVE: Evaluate cinnamic acid's effects on colitis in rats | ||
| 520 | |a METHODS: To induce colitis in experimental rats, excluding the sham group, a 4% intrarectal solution of acetic acid was administered. The rats were then given oral doses of cinnamic acid at 30, 45, and 90 mg/kg for two days. The animals were assessed for macroscopic and microscopic changes, and the levels of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO) were measured using Eliza kits. Additionally, real-time PCR was performed to examine the gene level of toll-like receptor 4 (TLR-4) in the colon | ||
| 520 | |a RESULTS: Effective reduction of inflammation in acetic acid-induced colitis was achieved through cinnamic acid at doses of 45 and 90 mg/kg. The decrease was achieved by inhibiting the activities of TNF-α, IL-6, and MPO while downregulating the expression of TLR-4. It is important to note that macroscopic and microscopic evaluations were significant in determining the effectiveness of cinnamic acid in reducing inflammation | ||
| 520 | |a CONCLUSION: Downregulation of inflammatory cytokines and TLR-4 expression may contribute to cinnamic acid's anti-inflammatory effect | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cinnamic acid; Inflammatory bowel disease (IBD); Interleukin-6 (IL-6); Myeloperoxidase (MPO); Toll-like recep-tor-4 (TLR-4); Tumor necrosis factor-alpha (TNF-α). | |
| 700 | 1 | |a Momtaz, Saeideh |e verfasserin |4 aut | |
| 700 | 1 | |a Gharazi, Pardis |e verfasserin |4 aut | |
| 700 | 1 | |a Rahimifard, Mahban |e verfasserin |4 aut | |
| 700 | 1 | |a Baeeri, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Abdollahi, Ali Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Abdollahi, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Niknejad, Amirhossein |e verfasserin |4 aut | |
| 700 | 1 | |a Khayatan, Danial |e verfasserin |4 aut | |
| 700 | 1 | |a Farzaei, Mohammad Hosein |e verfasserin |4 aut | |
| 700 | 1 | |a Abdolghaffari, Amir Hossein |e verfasserin |4 aut | |
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