The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
The time to arrest donors after circulatory death is unpredictable and can vary. This leads to variable periods of warm ischemic damage prior to pancreas transplantation. There is little evidence supporting procurement team stand-down times based on donor time to death (TTD). We examined what impact TTD had on pancreas graft outcomes following donors after circulatory death (DCD) simultaneous pancreas-kidney transplantation. Data were extracted from the UK transplant registry from 2014 to 2022. Predictors of graft loss were evaluated using a Cox proportional hazards model. Adjusted restricted cubic spline models were generated to further delineate the relationship between TTD and outcome. Three-hundred-and-seventy-five DCD simultaneous kidney-pancreas transplant recipients were included. Increasing TTD was not associated with graft survival (adjusted hazard ratio HR 0.98, 95% confidence interval 0.68-1.41, P = .901). Increasing asystolic time worsened graft survival (adjusted hazard ratio 2.51, 95% confidence interval 1.16-5.43, P = .020). Restricted cubic spline modeling revealed a nonlinear relationship between asystolic time and graft survival and no relationship between TTD and graft survival. We found no evidence that TTD impacts pancreas graft survival after DCD simultaneous pancreas-kidney transplantation; however, increasing asystolic time was a significant predictor of graft loss. Procurement teams should attempt to minimize asystolic time to optimize pancreas graft survival rather than focus on the duration of TTD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - (2024) vom: 14. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Malik, Abdullah K [VerfasserIn] |
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| Links: |
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| Themen: |
Graft outcome |
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| Anmerkungen: |
Date Revised 13.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.ajt.2024.02.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368502678 |
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| 100 | 1 | |a Malik, Abdullah K |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation |
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| 520 | |a The time to arrest donors after circulatory death is unpredictable and can vary. This leads to variable periods of warm ischemic damage prior to pancreas transplantation. There is little evidence supporting procurement team stand-down times based on donor time to death (TTD). We examined what impact TTD had on pancreas graft outcomes following donors after circulatory death (DCD) simultaneous pancreas-kidney transplantation. Data were extracted from the UK transplant registry from 2014 to 2022. Predictors of graft loss were evaluated using a Cox proportional hazards model. Adjusted restricted cubic spline models were generated to further delineate the relationship between TTD and outcome. Three-hundred-and-seventy-five DCD simultaneous kidney-pancreas transplant recipients were included. Increasing TTD was not associated with graft survival (adjusted hazard ratio HR 0.98, 95% confidence interval 0.68-1.41, P = .901). Increasing asystolic time worsened graft survival (adjusted hazard ratio 2.51, 95% confidence interval 1.16-5.43, P = .020). Restricted cubic spline modeling revealed a nonlinear relationship between asystolic time and graft survival and no relationship between TTD and graft survival. We found no evidence that TTD impacts pancreas graft survival after DCD simultaneous pancreas-kidney transplantation; however, increasing asystolic time was a significant predictor of graft loss. Procurement teams should attempt to minimize asystolic time to optimize pancreas graft survival rather than focus on the duration of TTD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a graft outcome | |
| 650 | 4 | |a pancreas transplantation: procurement | |
| 700 | 1 | |a Tingle, Samuel J |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Owen, Ruth |e verfasserin |4 aut | |
| 700 | 1 | |a Mahendran, Balaji |e verfasserin |4 aut | |
| 700 | 1 | |a Counter, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Sinha, Sanjay |e verfasserin |4 aut | |
| 700 | 1 | |a Muthasamy, Anand |e verfasserin |4 aut | |
| 700 | 1 | |a Sutherland, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Casey, John |e verfasserin |4 aut | |
| 700 | 1 | |a Drage, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a van Dellen, David |e verfasserin |4 aut | |
| 700 | 1 | |a Callaghan, Chris J |e verfasserin |4 aut | |
| 700 | 1 | |a Elker, Doruk |e verfasserin |4 aut | |
| 700 | 1 | |a Manas, Derek M |e verfasserin |4 aut | |
| 700 | 1 | |a Pettigrew, Gavin J |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Colin H |e verfasserin |4 aut | |
| 700 | 1 | |a White, Steven A |e verfasserin |4 aut | |
| 700 | 0 | |a NHSBT Pancreas Advisory Group |e verfasserin |4 aut | |
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