Erosions on T1-weighted MRI vs Radiography of Sacroiliac Joints in Recent-onset Axial SpA : 2-year Data (EMBARK Trial and DESIR Cohort)
OBJECTIVE: To (1) compare the capacity to detect sacroiliac joint (SIJ) erosions and baseline-to-Week-104 change in erosions between magnetic resonance imaging (MRI) and radiographs in recent-onset axial spondyloarthritis (axSpA); (2) compare treatment discriminatory capacities of MRI and radiographic scores for erosion detection in patients receiving etanercept in the EMBARK trial vs controls in the DESIR cohort.
METHODS: Anonymized SIJ MRI and radiographs were assessed at patient and joint surface levels. Three readers evaluated MRI; 3 different readers evaluated radiographs. Final scores for comparison of radiographs and MRI for detection of erosions were assigned based on agreement of ≥2 of 3 readers' assessments.
RESULTS: At baseline, discordance in erosion detection between imaging methods was more frequent for MRI erosions in the absence of radiographic erosions (48/224 [21.4%] patients) than for radiographic erosions in the absence of MRI erosions (14/224 [6.3%] patients; P<0.001). After 104 weeks, decrease in erosions was observed on MRI but not radiographs in 49 (22.2%) patients and on radiographs but not MRI in 6 (2.7%) (P<0.001). In the treatment-discriminant capacity analysis, the largest standardized differences between etanercept and control cohorts at Week 104 were changes in Spondyloarthritis Research Consortium of Canada MRI erosion discrete score, erosion average score, and meeting the modified New York criteria on radiographs, with unadjusted/adjusted Hedge's G effect sizes of 0.40/0.50, 0.40/0.56, and 0.40/0.43, respectively.
CONCLUSION: In recent-onset axSpA, SIJ erosions and erosion change were observed more frequently on MRI than radiography. The significance of interval improvement of MRI erosions warrants further research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The Journal of rheumatology - (2024) vom: 15. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maksymowych, Walter P [VerfasserIn] |
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| Anmerkungen: |
Date Revised 15.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.3899/jrheum.2023-0906 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368500233 |
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| 041 | |a eng | ||
| 100 | 1 | |a Maksymowych, Walter P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Erosions on T1-weighted MRI vs Radiography of Sacroiliac Joints in Recent-onset Axial SpA |b 2-year Data (EMBARK Trial and DESIR Cohort) |
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| 500 | |a Date Revised 15.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
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| 520 | |a OBJECTIVE: To (1) compare the capacity to detect sacroiliac joint (SIJ) erosions and baseline-to-Week-104 change in erosions between magnetic resonance imaging (MRI) and radiographs in recent-onset axial spondyloarthritis (axSpA); (2) compare treatment discriminatory capacities of MRI and radiographic scores for erosion detection in patients receiving etanercept in the EMBARK trial vs controls in the DESIR cohort | ||
| 520 | |a METHODS: Anonymized SIJ MRI and radiographs were assessed at patient and joint surface levels. Three readers evaluated MRI; 3 different readers evaluated radiographs. Final scores for comparison of radiographs and MRI for detection of erosions were assigned based on agreement of ≥2 of 3 readers' assessments | ||
| 520 | |a RESULTS: At baseline, discordance in erosion detection between imaging methods was more frequent for MRI erosions in the absence of radiographic erosions (48/224 [21.4%] patients) than for radiographic erosions in the absence of MRI erosions (14/224 [6.3%] patients; P<0.001). After 104 weeks, decrease in erosions was observed on MRI but not radiographs in 49 (22.2%) patients and on radiographs but not MRI in 6 (2.7%) (P<0.001). In the treatment-discriminant capacity analysis, the largest standardized differences between etanercept and control cohorts at Week 104 were changes in Spondyloarthritis Research Consortium of Canada MRI erosion discrete score, erosion average score, and meeting the modified New York criteria on radiographs, with unadjusted/adjusted Hedge's G effect sizes of 0.40/0.50, 0.40/0.56, and 0.40/0.43, respectively | ||
| 520 | |a CONCLUSION: In recent-onset axSpA, SIJ erosions and erosion change were observed more frequently on MRI than radiography. The significance of interval improvement of MRI erosions warrants further research | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Claudepierre, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a de Hooge, Manouk |e verfasserin |4 aut | |
| 700 | 1 | |a Lambert, Robert G |e verfasserin |4 aut | |
| 700 | 1 | |a Landewé, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Molto, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a van der Heijde, Désirée |e verfasserin |4 aut | |
| 700 | 1 | |a Bukowski, Jack F |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Heather |e verfasserin |4 aut | |
| 700 | 1 | |a Pedersen, Ron |e verfasserin |4 aut | |
| 700 | 1 | |a Szumski, Annette |e verfasserin |4 aut | |
| 700 | 1 | |a Vlahos, Bonnie |e verfasserin |4 aut | |
| 700 | 1 | |a Dougados, Maxime |e verfasserin |4 aut | |
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