Cumulative live birth rate of in vitro fertilization cycle via progestin-primed ovarian stimulation versus gonadotropin-releasing hormone antagonist protocol in infertile women with normal ovarian reserve : an open-label, randomized controlled trial
This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) protocol for in vitro fertilization (IVF) cycle in infertile women with normal ovarian reserve (NOR). Infertile women with NOR who underwent their first IVF cycle were enrolled in an open-label randomized controlled trial. Patients were randomly assigned 1:1 to receive a freeze-all strategy with delayed embryo transfer (PPOS group, n = 174) and fresh embryo transfer first (GnRH-ant group, n = 174). The primary outcome was the cLBR per aspiration. The cLBR between the PPOS group and GnRH-ant group were comparable (55.75% vs. 52.87%, p = 0.591). A premature luteinizing hormone surge was not observed in the PPOS group, while there were six cases (3.45%) in the GnRH-ant group, but no premature ovulation in either of the groups. The pregnancy outcomes, including implantation rate, clinical pregnancy rate and miscarriage rate, were all comparable. In addition, the number of retrieved oocytes, mature oocytes and viable embryos were similar (all p > 0.05) between the two groups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Human fertility (Cambridge, England) - 27(2024), 1 vom: 15. Feb., Seite 2316005 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ye, Hongjuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.02.2024 Date Revised 16.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14647273.2024.2316005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368480372 |
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| 245 | 1 | 0 | |a Cumulative live birth rate of in vitro fertilization cycle via progestin-primed ovarian stimulation versus gonadotropin-releasing hormone antagonist protocol in infertile women with normal ovarian reserve |b an open-label, randomized controlled trial |
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| 500 | |a Date Revised 16.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) protocol for in vitro fertilization (IVF) cycle in infertile women with normal ovarian reserve (NOR). Infertile women with NOR who underwent their first IVF cycle were enrolled in an open-label randomized controlled trial. Patients were randomly assigned 1:1 to receive a freeze-all strategy with delayed embryo transfer (PPOS group, n = 174) and fresh embryo transfer first (GnRH-ant group, n = 174). The primary outcome was the cLBR per aspiration. The cLBR between the PPOS group and GnRH-ant group were comparable (55.75% vs. 52.87%, p = 0.591). A premature luteinizing hormone surge was not observed in the PPOS group, while there were six cases (3.45%) in the GnRH-ant group, but no premature ovulation in either of the groups. The pregnancy outcomes, including implantation rate, clinical pregnancy rate and miscarriage rate, were all comparable. In addition, the number of retrieved oocytes, mature oocytes and viable embryos were similar (all p > 0.05) between the two groups | ||
| 650 | 4 | |a Clinical Trial Protocol | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Female infertility | |
| 650 | 4 | |a This trial was registered in the China Clinical Trial Registry on 6 September 2018 (ChiCTR1800018246) | |
| 650 | 4 | |a gonadotropin-releasing hormone antagonist | |
| 650 | 4 | |a in vitro fertilization | |
| 650 | 4 | |a ovarian reserve | |
| 650 | 4 | |a ovarian stimulation | |
| 650 | 4 | |a progestin | |
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| 650 | 7 | |a Gonadotropin-Releasing Hormone |2 NLM | |
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| 650 | 7 | |a Hormone Antagonists |2 NLM | |
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| 700 | 1 | |a Quan, Xinxin |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Huilan |e verfasserin |4 aut | |
| 700 | 1 | |a Xue, Songguo |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Zhao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Qiuju |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Lihua |e verfasserin |4 aut | |
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