Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies
Copyright © 2024 Cai, Deng, Yang, Pan, Liang, Yang, Song, Xiao and Li..
Introduction: Pregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear.
Methods: In this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants.
Results: We found significant differences in serum metabolite levels between infants born from mothers with SLE and those born from mothers without SLE, including 15 metabolites with reduced serum levels. Further analysis revealed a disrupted tyrosine metabolism pathway in the offspring of mothers with SLE.
Discussion: By constructing a composite model incorporating various factors, such as serum tyrosine levels, gestational age, and birth weight, we were able to accurately differentiate between newborns of SLE and non-SLE pregnancies. Our data reveal significant differences in serum concentrations of amino acids and acylcarnitines in newborns born to mothers with SLE. We conclude that the reduction of blood L-tyrosine levels is a feature that is characteristic of adverse neurological outcomes in infants born from mothers with SLE.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Frontiers in immunology - 15(2024) vom: 15., Seite 1335042 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cai, Yao [VerfasserIn] |
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| Links: |
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| Themen: |
42HK56048U |
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| Anmerkungen: |
Date Completed 16.02.2024 Date Revised 09.04.2024 published: Electronic-eCollection CommentOn: RMD Open. 2023 Feb;9(1):. - PMID 37185223 Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2024.1335042 |
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| PPN (Katalog-ID): |
NLM368476413 |
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| 245 | 1 | 0 | |a Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies |
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| 500 | |a Date Revised 09.04.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a CommentOn: RMD Open. 2023 Feb;9(1):. - PMID 37185223 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Cai, Deng, Yang, Pan, Liang, Yang, Song, Xiao and Li. | ||
| 520 | |a Introduction: Pregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear | ||
| 520 | |a Methods: In this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants | ||
| 520 | |a Results: We found significant differences in serum metabolite levels between infants born from mothers with SLE and those born from mothers without SLE, including 15 metabolites with reduced serum levels. Further analysis revealed a disrupted tyrosine metabolism pathway in the offspring of mothers with SLE | ||
| 520 | |a Discussion: By constructing a composite model incorporating various factors, such as serum tyrosine levels, gestational age, and birth weight, we were able to accurately differentiate between newborns of SLE and non-SLE pregnancies. Our data reveal significant differences in serum concentrations of amino acids and acylcarnitines in newborns born to mothers with SLE. We conclude that the reduction of blood L-tyrosine levels is a feature that is characteristic of adverse neurological outcomes in infants born from mothers with SLE | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Comment | |
| 650 | 4 | |a mass spectrometry | |
| 650 | 4 | |a metabolomics | |
| 650 | 4 | |a newborn | |
| 650 | 4 | |a offspring | |
| 650 | 4 | |a systemic lupus erythematosus | |
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| 700 | 1 | |a Deng, Zhirong |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Qiuping |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Guixian |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Zao |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Ximei |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Sitao |e verfasserin |4 aut | |
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