PITUITARY FUNCTIONS AFTER RECOVERY FROM COVID-19
©2023 Acta Endocrinologica (Buc)..
Context: Injury and functional disorders in pituitary gland after COVID-19 still need elucidation.
Objective: To investigate pituitary functions, particularly hypothalamic pituitary adrenal (HPA) axis after COVID-19 infection.
Methods: This study was conducted at a university hospital between May and October 2021. Patients who had COVID-19, were enrolled as study group, three months after recovery. Participants who do not have COVID-19 diagnosis, with similar characteristics were included as control group. Blood samples were taken on the morning at 08 AM. Adrenal stimulation test was performed with 1 µg of ACTH (Synacthen).
Results: The study group included 50 patients and control group was 49 cases. One (2%) out of the 50 patients with 8 a.m. serum cortisol below 5 µg/dL. Low serum ACTH levels were detected in 7 (14%) participants in patient group. Stimulation with 1 µg of ACTH (Synacthen) test was performed for 2 (4%) of 50 patients with serum cortisol below 10 µg/dL. Both patients achieved a peak cortisol of over 12.5 µg/dL after stimulation. Standard deviation (SD) score for insulin like growh factor-1 (IGF-1) was lower than -2 SD for age and gender in 7 (14%) patients. TSH levels was mildly increased in five (10%) patients. There was no significant difference in baseline pituitary hormone levels in study and control groups.
Conclusion: Basal pituitary hormone levels and HPA axes were found to be preserved and competently functioning in patients who experienced mild/moderate COVID-19. However, symptoms observed after COVID-19 episode were evident in substantial amount of patients in this study and these symptoms were not associated with changes in pituitary gland function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Acta endocrinologica (Bucharest, Romania : 2005) - 19(2023), 3 vom: 09. Juli, Seite 314-318 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaya, M G [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenal insufficiency |
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| Anmerkungen: |
Date Revised 16.02.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4183/aeb.2023.314 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368470873 |
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| 500 | |a Date Revised 16.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a ©2023 Acta Endocrinologica (Buc). | ||
| 520 | |a Context: Injury and functional disorders in pituitary gland after COVID-19 still need elucidation | ||
| 520 | |a Objective: To investigate pituitary functions, particularly hypothalamic pituitary adrenal (HPA) axis after COVID-19 infection | ||
| 520 | |a Methods: This study was conducted at a university hospital between May and October 2021. Patients who had COVID-19, were enrolled as study group, three months after recovery. Participants who do not have COVID-19 diagnosis, with similar characteristics were included as control group. Blood samples were taken on the morning at 08 AM. Adrenal stimulation test was performed with 1 µg of ACTH (Synacthen) | ||
| 520 | |a Results: The study group included 50 patients and control group was 49 cases. One (2%) out of the 50 patients with 8 a.m. serum cortisol below 5 µg/dL. Low serum ACTH levels were detected in 7 (14%) participants in patient group. Stimulation with 1 µg of ACTH (Synacthen) test was performed for 2 (4%) of 50 patients with serum cortisol below 10 µg/dL. Both patients achieved a peak cortisol of over 12.5 µg/dL after stimulation. Standard deviation (SD) score for insulin like growh factor-1 (IGF-1) was lower than -2 SD for age and gender in 7 (14%) patients. TSH levels was mildly increased in five (10%) patients. There was no significant difference in baseline pituitary hormone levels in study and control groups | ||
| 520 | |a Conclusion: Basal pituitary hormone levels and HPA axes were found to be preserved and competently functioning in patients who experienced mild/moderate COVID-19. However, symptoms observed after COVID-19 episode were evident in substantial amount of patients in this study and these symptoms were not associated with changes in pituitary gland function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adrenal insufficiency | |
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