Construction of an Angular Tricyclic Benzofuran Skeleton Using the C-H Activation Strategy
A protocol for the construction of an angular tricyclic benzofuran skeleton based on the C-H activation strategy has been established. Different phthalide lactones on this skeleton can be easily assembled with various side chains by using C-H activation with aldehydes and subsequent reduction. This skeleton provides a versatile and crucial motif for the total synthesis of naturally occurring angular tricyclic benzofurans and their derivatives. Based on this protocol, the improved total syntheses of daldinin A and annullatin D were achieved in yields of 17.3 and 7.6%, respectively.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
The Journal of organic chemistry - 89(2024), 5 vom: 01. März, Seite 3304-3308 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Qianqian [VerfasserIn] |
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| Anmerkungen: |
Date Revised 01.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.joc.3c02754 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368464741 |
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| 520 | |a A protocol for the construction of an angular tricyclic benzofuran skeleton based on the C-H activation strategy has been established. Different phthalide lactones on this skeleton can be easily assembled with various side chains by using C-H activation with aldehydes and subsequent reduction. This skeleton provides a versatile and crucial motif for the total synthesis of naturally occurring angular tricyclic benzofurans and their derivatives. Based on this protocol, the improved total syntheses of daldinin A and annullatin D were achieved in yields of 17.3 and 7.6%, respectively | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Guo, Feixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yizhe |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kunyi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yakun |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Qinghe |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Vuanghao |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Yingchao |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Lizhen |e verfasserin |4 aut | |
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