Retinopathy as a predictive indicator for significant hepatic fibrosis according to T2DM status : A cross-sectional study based on the national health and nutrition examination survey data
Copyright © 2024 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved..
INTRODUCTION AND OBJECTIVES: Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with a range of complications, with retinopathy being particularly common. Recent studies have shed light on a potential connection between diabetic retinopathy (DR) and hepatic fibrosis, indicating a possible shared pathophysiological foundation in T2DM. This study investigates the correlation between retinopathy and hepatic fibrosis among individuals with T2DM, as well as evaluates the diagnostic value of DR for significant hepatic fibrosis.
MATERIALS AND METHODS: Our cross-sectional analysis incorporated 5413 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. The Fibrosis-4 score (FIB-4) classified hepatic fibrosis into different grades (F0-F4), with significant hepatic fibrosis marked as F2 or higher. Retinopathy severity was determined using retinal imaging and categorized into four levels. The analysis of variance or Chi-square tests facilitated group comparisons. Additionally, the receiver operating characteristic (ROC) analysis appraised the predictive accuracy of retinopathy for significant hepatic fibrosis in the T2DM population.
RESULTS: Among 5413 participants, the mean age was 59.56 ± 12.41, with 50.2% male. And 20.6% were diagnosed with T2DM. Hepatic fibrosis grading was positively associated with retinopathy severity (OR [odds ratio]: 1.521, 95%CI [confidence interval]: 1.152-2.008, P = 0.003) across the entire population. The association was amplified in the T2DM population according to Pearson's analysis results. The ROC curve demonstrated retinopathy's diagnostic capacity for significant hepatic fibrosis in the T2DM population (AUC [area under curve] = 0.72, 95%CI: 0.651-0.793, P < 0.001).
CONCLUSIONS: Retinopathy could serve as an independent predictor of significant hepatic fibrosis in T2DM population. Ophthalmologists are advised to closely monitor T2DM patients with retinopathy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Annals of hepatology - 29(2024), 4 vom: 12. Feb., Seite 101478 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Jinze [VerfasserIn] |
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| Links: |
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| Themen: |
Hepatic fibrosis |
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| Anmerkungen: |
Date Revised 03.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.aohep.2024.101478 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36845049X |
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| 100 | 1 | |a Li, Jinze |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Retinopathy as a predictive indicator for significant hepatic fibrosis according to T2DM status |b A cross-sectional study based on the national health and nutrition examination survey data |
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| 520 | |a Copyright © 2024 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a INTRODUCTION AND OBJECTIVES: Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with a range of complications, with retinopathy being particularly common. Recent studies have shed light on a potential connection between diabetic retinopathy (DR) and hepatic fibrosis, indicating a possible shared pathophysiological foundation in T2DM. This study investigates the correlation between retinopathy and hepatic fibrosis among individuals with T2DM, as well as evaluates the diagnostic value of DR for significant hepatic fibrosis | ||
| 520 | |a MATERIALS AND METHODS: Our cross-sectional analysis incorporated 5413 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. The Fibrosis-4 score (FIB-4) classified hepatic fibrosis into different grades (F0-F4), with significant hepatic fibrosis marked as F2 or higher. Retinopathy severity was determined using retinal imaging and categorized into four levels. The analysis of variance or Chi-square tests facilitated group comparisons. Additionally, the receiver operating characteristic (ROC) analysis appraised the predictive accuracy of retinopathy for significant hepatic fibrosis in the T2DM population | ||
| 520 | |a RESULTS: Among 5413 participants, the mean age was 59.56 ± 12.41, with 50.2% male. And 20.6% were diagnosed with T2DM. Hepatic fibrosis grading was positively associated with retinopathy severity (OR [odds ratio]: 1.521, 95%CI [confidence interval]: 1.152-2.008, P = 0.003) across the entire population. The association was amplified in the T2DM population according to Pearson's analysis results. The ROC curve demonstrated retinopathy's diagnostic capacity for significant hepatic fibrosis in the T2DM population (AUC [area under curve] = 0.72, 95%CI: 0.651-0.793, P < 0.001) | ||
| 520 | |a CONCLUSIONS: Retinopathy could serve as an independent predictor of significant hepatic fibrosis in T2DM population. Ophthalmologists are advised to closely monitor T2DM patients with retinopathy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hepatic fibrosis | |
| 650 | 4 | |a National Health and Nutrition Examination Survey | |
| 650 | 4 | |a Predictive indicator | |
| 650 | 4 | |a Retinopathy | |
| 650 | 4 | |a Type 2 diabetes mellitus | |
| 700 | 1 | |a Xiang, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Jiahao |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Youfang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ruiying |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Zihe |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Huihui |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Ruixia |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Teng, Gao-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Xiaolong |e verfasserin |4 aut | |
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